Teva Pharmaceutical Industries Limited

Other

Yeda Research and Develpment & Co. Ltd

Hasleton, Mark

Anton Frenkel

Avital Laxer

Ramy Lidor-Hadas

Tamas Koltai

Muhammad Safadi

Eduard Gurevich

Eliezer Bahar

Rachel Cohen

Marina Zholkovsky

Ronen Ben-David

Danit Licht

Michal Keisar

Ben-Zion Dolitzky

Ruth Arnon

Daniella Licht

Rina Aharoni

Ramy Lidor

Michal Schwartz

Raeann Ruiyun Wu

Raeann Ruiyun

Gsan Attili

Irit Pinchasi

Judith Aronheim

The present disclosure relates to a new salt of escitalopram and its solid state forms, processes for the preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

Salt and solid state forms of escatalopram

Salt and solid state forms of escitalopram

The subject invention provides R(+)-N-formyl-propargyl-aminoindan and a composition containing N-propargyl-1(R)-aminoindan or a pharmaceutically acceptable salt thereof, and a compound of R(+)-N-formyl-propargyl-aminoindan.

R(+)-N-formyl-propargyl-aminoindan

The subject invention provides R(+)-N-methyl-propargyl-aminoindan or a pharmaceutically acceptable salt thereof and a composition containing R(+)-N-propargyl-1(R)-aminoindan or a pharmaceutically acceptable salt thereof, and a compound of R(+)-N-methyl-propargyl-aminoindan or a salt thereof.

R(+)-N-methyl-propargyl-aminoindan

The subject invention provides a mixture of crystalline laquinimod sodium particles, wherein (i) 90% or more of the total amount by volume of the laquinimod sodium particles have a size of 40 microns or less or (ii) 50% or more of the total amount by volume of the laquinimod sodium particles have a size of 15 microns or less, and wherein:

Crystals of laquinimod sodium and improved process for the manufacture thereof

The subject invention provides a Laquinimod amine salt, which is laquinimod meglumine, laquinimod choline hydroxide, laquinimod L-lysine or laquinimod monoethanolamine.

Amine salts of laquinimod

Disclosed is a process for the preparation of laquinimod sodium which removes the impurities after the salt formation step, thus resulting in crystals of higher purity as well as crystals having improved crystalline characteristics.

Crystals of laquinimod sodium, and process for the manufacture thereof

Disclosed is a process for the preparation of laguinimod sodium which removes the impurities after the salt formation step, thus resulting in crystals of higher purity as well as crystals having improved crystalline characteristics.

The subject invention provides crystalline R(+)-N-propargyl-1-aminoindan, pharmaceutical compositions and methods of manufacture thereof.

Crystalline solid rasagiline base

Disclosed is crystalline R(+)-N-propargyl-1-aminoindan and racemic N-propargyl-1-aminoindan characterized by colorless crystals a pharmaceutical composition comprising the same, and the process for the manufacture and the validation thereof. Also disclosed is pure liquid R(+)-N-propargyl-1-aminoindan and a pharmaceutical composition comprising the same, and the process for the manufacture thereof.

Process for purifying rasagiline base

Disclosed is crystalline R(+)-N-propargyl-1-aminoindan containing water at an amount of less than 0.5% by weight and a pharmaceutical composition comprising the same, and the process for the manufacture and the validation thereof. Also disclosed is a process for the preparation of solid rasagiline base.

Process for preparing and drying solid rasagiline base

Disclosed are formulations which are designed to delay release of rasagiline while maintaining specific pharmacokinetic properties.

Delayed release rasagiline citrate formulation

Disclosed is crystalline R(+)-N-propargyl-l-aminoindan containing water at an amount of less than 0.5% by weight and a pharmaceutical composition comprising the same, and the process for the manufacture and the validation thereof. Also disclosed is a process for the preparation of solid rasagiline base.

The subject invention provides rasagiline citrate, its compositions and processes for the manufacture thereof.

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Netanya, Israel

Anton Frenkel