Pfizer Corporation

Biopharma Works LLC

Systamedic Inc.

Anton Franz Joseph Fliri

Randall James Gallaschun

Todd William Butler

Robert A Volkmann

Anthony Marfat

Peter Cornelius

Panayiotis Zagouras

Jacob Bradley Schwarz

Christopher John O'Donnell

John Anthony Ragan

Brian Patrick Jones

Barbara Eileen Segelstein

Frederick Nelson

Fredrick Raymond Nelson

A method of tracking information flows through multiple network systems includes selecting a primary network system from a population of primary and secondary network systems, wherein each of the primary and secondary network systems include network nodes, selecting first selected characteristic features that identify network nodes of the primary network system that provide interaction between the selected primary network system and secondary network systems, identifying at least one secondary network system that is capable of interacting with the network nodes of the primary network system, subdividing the primary network into subnetwork systems based on identifying primary network nodes that provide interaction between the primary network system and secondary network nodes, identifying the subnetwork systems that are capable of interacting with one or more network nodes of the secondary network systems, identifying a subnetwork node count of the primary network nodes in each subnetwork, identifying objects that are capable of interacting with the primary network nodes, and determining a coincidence frequency or a coincidence measurement between features of objects interacting with the primary network nodes and the features of the primary network nodes that indicate information exchanges between the primary and secondary network nodes.

Method and descriptors for comparing object-induced information flows in a plurality of interaction networks

The aspects of the disclosed embodiments are directed to novel compounds, specifically, quaternary ammonium derivatives of tertiary amine containing opioid drug compounds such as hydrocodone, hydromorphone and oxycodone, formulations containing said. compounds or pharmaceutically acceptable salts thereof, which are capable of providing controlled release of the opioid drug upon administration to a patient in order to treat pain.

Compounds for treatment of pain

The invention is directed to novel compounds, formulations containing said compounds or pharmaceutically acceptable salts thereof which are suitable for administration to a patient.

The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.

Growing community of inventors

Stonington, CT, United States of America

Anton Franz Joseph Fliri