Xencor, Inc.

Other

Anton Filikov

Bassil I Dahiyat

John R Desjarlais

Jonathan Zalevsky

Umesh Muchhal

David Szymkowski

Paul Michael Steed

Malu Lourdes G Tansey

Malu Tansey

The invention relates to novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-alpha related disorders.

Treatment of TNF-&#x3b1; related disorders with TNF-&#x3b1; variant proteins

TNF-alpha variants proteins for the treatment of TNF-alpha related disorders

Descriptors of cohesive interactions in the solid state are calculated from a computational model of a solid state, i.e. from a small cluster of copies of the molecule of interest assembled using a molecular mechanics method. A model for predicting solubility is built using the cohesive interaction descriptors along with other descriptors useful for this purpose. Predicted solubility is computed for the compound of interest by computing the same descriptors and applying the solubility model. Explicit modeling of solid state allows to more accurately characterize cohesive interactions in solids, hence, more accurately predict solubility.

Method of prediction of solubility of chemical compounds

The invention relates to novel proteins with TNF-&#x3b1; antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-&#x3b1; related disorders, such as rheumatoid arthritis.

TNF-&#x3b1;variants

TNF-&#x3b1; variants

The invention relates to novel growth hormone activity (GHA) proteins and nucleic acids. The invention further relates to the use of the GHA proteins in the treatment of growth hormone related disorders.

Nucleic acids and proteins with growth hormone activity

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Wakefield, MA, United States of America

Anton Filikov