F-Star Biotechnologische Forschungs- Und Entwicklungsges.m.b.h

Other

Anton Bauer

Gottfried Himmler

Geert Mudde

Gerda Redl

Maximillian Woisetschlager

Gordana Wozniak-Knopp

Emilio Manuel Casanova Hevia

Leander Blaas

Maximilian Woisetschlaeger

The invention relates to a cytotoxic modular antibody with a molecular weight of up to 60 kD, specifically binding to a cell surface target with a binding affinity of Kd&#x3c;10M, a method of producing such antibody and its use as a therapeutic.

Cytotoxic immunoglobulin

The invention relates to a cytotoxic modular antibody with a molecular weight of up to 6 OkD, specifically binding to a cell surface target with a binding affinity of Kd&#x3c;10M, a method of producing such antibody and its use as a therapeutic.

According to the present invention there is provided a method of producing a protein in a eukaryotic cell line, comprising the steps of a) providing a backbone of an artificial chromosome, b) recombining the nucleic acid encoding said protein into said backbone to generate an expression vector, c) introducing said expression vector into a eukaryotic host cell line to obtain a eukaryotic expression cell line, d) cultivating said expression cell line to produce said protein, and e) isolating said protein. The invention further relates to respective vectors and transgenic cell lines.

Artificial chromosome vector

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Wagram, Austria

Anton Bauer