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Centre National De La Recherche Scientifique

Biomerieux, Inc.

Université De Nantes

Hospices Civils De Lyon

Université Paris-sud 11

Centre Hospitalier Universitaire De Nantes

Antoine Roquilly

Karim Asehnoune

Guillaume Monneret

Fabienne Venet

Tanguy Fortin

Alexandre Pachot

Sylvie Pons

Marie-Pierre Fontaine-Aupart

Marilyne Dupin

Aurélie Gouel-Cheron

Audrey Larue-Triolet

Bernard Allaouchiche

Sandrine Lecart

Antoine Monsel

A method for predicting the risk of developing a disseminated infection in a patient admitted to intensive care having no clinical symptoms of such infection includes: determining a first dose of gelsolin G1 in a biological sample from the patient originating from a first sample taken at time T1, carried out between the day of intensive care admission and 48 hours afterward; determining a second dose of gelsolin G2 in a biological sample from the patient originating from a second sample taken at time T2, carried out two to three days after the first sampling; calculating the variation between the dose of gelsolin G2 and the dose of gelsolin G1, giving a &#x394; value; and comparing the &#x394; value to a threshold value S determined beforehand from two patient populations admitted to intensive care, one not having developed a disseminated infection and the other having developed such an infection.

Prediction of the risk of developing a disseminated infection for patients admitted to an intensive care unit

The present invention relates to an in vitro method for diagnosing the infectious state of an individual on the basis of a sample of white corpuscles arising from a biological specimen taken from an organ potentially infected by a pathogenic microorganism of said individual, comprising at least the following two steps: i) measuring the mean cellular intensity of the autofluorescence of said sample, and ii) comparing the intensity measured in step i) with a control value, so as to determine the infectious state of said individual. The diagnostic method of the invention uses a routine optical material making it possible to work in wavelength regions which are compatible with the cellular autofluorescence, and thus constitutes a rapid, reliable and inexpensive aid for the diagnosis or monitoring of an infection in an individual.

Cytological method using the auto fluorescence of white corpuscles for the early diagnosis and the monitoring of infections

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Caulfield North, Australia

Antoine Roquilly