Institut National De La Sante Et De La Recherche Medicale

Université De Rennes 1

Universite Des Antilles Et De La Guyane

Antoine Rolland

Charles Pineau

Pierre Calvel

Regis Lavigne

Testicular germline markers and their use for predicting the presence or not of reproductive cells in testis of an infertile or hypo fertile male subject are provided. More particularly, identification of specific protein biomarkers of post-meiotic germ cells in the human seminal plasma was carried out by an integrative genomics approach. It was demonstrated that the presence of such biomarkers could be monitored in the seminal plasma of azoospermic subjects in order to select for a testis biopsy and testicular sperm extraction (TESE) only subjects for which there are high probabilities to find reproductive cells. The results indicate the analysis of seminal plasma is a non-invasive approach for predicting the presence of reproductive cells.

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Rennes, France

Antoine Rolland