Laboratoires Expanscience

Laboratories Expanscience

Pharmascience Inc.

Laboratoires Pharmascience

Antoine Piccirilli

Philippe Msika

Nathalie Piccardi

François Paul

Jacques Legrand

Stéphanie Bredif

Nicole Broutin

Jean-Christophe Choulot

Francois Paul

Jacqueline Smadja

Isabelle Grondin

Micka&euml;l Boisseau

Jo&euml; Barrault

Yannick Pouilloux

Carole Kohler

Sandrine Bardet

The invention relates to a medicament which comprises a peptide extract of avocado and which can also comprise a composition containing D-mannoheptulose an/or perseitol, such as a water-soluble extract of avocado sugars, and/or a peptide extract of lupine. The inventive medicament is intended for the treatment and/or prevention of illnesses that are linked to an alteration in innate and/or acquired immunity, through an increase in the production of anti-microbial peptides, preferably hBD-2, without inducing inflammatory reactions, irritations or intolerances.

Medicament comprising a peptide extract of avocado, which is intended for the treatment and prevention of illnesses that are linked to an immune system deficiency or oxidative stress or skin ageing or dry skin

The invention relates to the use of a compound comprising D-mannoheptulose and/or perseitol for producing a drug for treating and/or preventing diseases related to the modification of an innate and/or acquired immunity by increasing the production of antimicrobial peptides, preferably hBD-2 without inducing inflammatory reactions, irritation or intolerance. Said compound can also comprise a peptidic avocado extract an/or a peptidic lupin extract.

Use of a compound comprising D-mannoheptulose and/or perseitol for treating and preventing innate immunity modification diseases

The invention relates to using one or several synthetic or natural furan alkyls for preparing a drug for preventing and/or treating diabetes and insulin resistance, thereby preventing the risks of cardiovascular, nervous, cutaneous, renal, ocular and infectious diseases. The use of one or several synthetic or natural furan alkyls for cosmetically treating diabetes related skin disorders is also disclosed.

Use of furan alkyl for preparing an antidiabetic drug

The present invention relates to the use of a lupeol-rich extract for the production of a cosmetic or pharmaceutical composition for treating and/or preventing a connective tissue degeneration. Said invention also relates to the use of a lupeol-rich extract for the production of a pharmaceutical composition for preventing and/or treating non-inflammatory articular pathologies, periodontal diseases and stretch marks. The invention also relates to the use of a lupeol-rich extract for the production of a cosmetic composition as a cicatrizing agent, a restructuring agent and an anti-sagging agent for skin and/or mucosae.

Use of a cosmetic of pharmaceutical composition, comprising a lupeol-rich extract as an active ingredient for stimulating the synthesis of heat shock proteins

The invention relates to a composition comprising a lupin total extract consisting of a lupin sugar extract, comprising at least 50% galactooligosaccharides by weight, in relation to the weight of dry matter, and a lupin peptide extract. The composition can also contain a chromane derivative or a chromene derivative. The invention also relates to a pharmaceutical and/or cosmetic composition comprising said lupin total extract, used advantageously as an anti-inflammatory agent, which repairs the cutaneous barrier and heals, used particularly in the prevention and/or treatment of erythemas.

Lupin total extract consisting of a lupin sugar extract and a lupin peptide extract, method for the production and use thereof

The invention concerns a composition containing at least an oxazolin, optionally combined with at least a compound such as a metalloprotease inhibitor, a PKC inhibitor, an anti-inflammatory agent, a soothing agent, an immunosuppressor, an ion chelating agent, an alkanolamide, an oxazolidinone and a carbamic acid derivative. The invention also concerns the use of such a composition as medicine, in particular for preventing or treating skin pathologies of allergic and/or inflammatory and/or irritative origin or resulting from a danger signal. The invention further concerns a method for cosmetic treatment of sensitive, irritated, intolerant, allergy-prone, ageing skin and/or mucosa exhibiting skin barrier disorder, or exhibiting non-pathological immunologic imbalance, which consists in applying such composition on the skin and/or mucosa.

Composition comprising at least one oxazoline to inhibit migration of langerhans cells, and uses thereof

The invention relates to a medicament which comprises a peptide extract of avocado and which can also comprise a composition containing D-mannoheptulose and/or perseitol, such as a water-soluble extract of avocado sugars, and/or a peptide extract of lupine. The inventive medicament is intended for the treatment and/or prevention of illnesses that are linked to an alteration in innate and/or acquired immunity, through an increase in the production of anti-microbial peptides, preferably hBD-2, without inducing inflammatory reactions, irritations or intolerances.

Medicament comprising a peptide extract of avocado, which is intended for the treatment and prevention of illnesses that are linked to an immune system deficiency

The invention concerns the use of at least a fatty ester for preparing a composition designed to inhibit 5&#x3b1;-reductase activity. Said use produces a remarkable inhibiting effect of 5&#x3b1;-reductase thereby providing a novel response for treating dermatological pathologies and/or disorders related to congenital or acquired exaggeration of 5&#x3b1;-reductase activity, in particular for treating prostatic hypertrophy, prostatic adenoma, acne, hyperseborrhea, alopecia and hirsutism. The invention also concerns cosmetic treatment methods, in particular for greasy skin, and the use of said fatty esters as additives in a food product for human and/or animal consumption.

Use of at least a fatty ester for preparing a composition designed to inhibit 5-&#x3b1;-reductase activity, in pharmacology, in particular dermatology, in cosmetics and as food additive

The invention concerns a composition containing at least an alkanolamide, optionally combined with at least a compound such as a metalloprotease inhibitor, a PKC inhibitor, an anti-inflammatory agent, a soothing agent, an immunosuppressor, an ion chelating agent, an oxazolin, an oxazolidinone and a carbamic acid derivative. The invention also concerns the use of such a composition as medicine, in particular its use for preventing or treating skin pathologies of allergic and/or inflammatory and/or irritative origin or resulting from a danger signal. The invention further concerns a method for cosmetic treatment of sensitive, irritated, intolerant, allergy-prone, ageing skin and/or mucosa exhibiting skin barrier disorder, or exhibiting non-pathological immunologic imbalance, which consists in applying such a composition on the skin and/or mucosa.

Composition comprising at least one alkanolamide to inhibit migration of langerhans cells and uses therof

Composition comprising at least one oxazoline for inhibiting langerhans cell migration, and uses thereof

The invention concerns the use of at least a vegetable oil product selected among the group consisting of vegetable oil oleic distillates, vegetable oil unsaponifiable matters, vegetable oil furan lipids and mixtures thereof, as agents for increasing skin lipid synthesis, in particular lipids of the epidermal skin barrier, in or for preparing a composition containing a pharmaceutically or dermatologically acceptable medium. The use enables to prevent and/or treat deterioration of the skin barrier (dry skin, skin subjected to actinic radiation, ichthyosis, acne, xerosis, atopic dermatitis, sensitive skin, chafing and reactive skin, itching and the like).

Use of a plant oil product as an agent for increasing the synthesis of skin lipids

The present invention relates to the use of a plant oil product as an agent for increasing the synthesis of skin lipids, especially the lipids of the epidermal skin barrier, in or for the preparation of a cosmetic, pharmaceutical or dermatological composition. The invention also relates to a method for cosmetic treatment with a cosmetic, pharmaceutical or dermatological composition for increasing the synthesis of skin lipids, especially the lipids of the epidermal skin barrier, and to the use of the plant product as a food additive.

The invention relates to the use of a compound comprising D-mannoheptulose and/or perseitol for producing a drug for treating and/or preventing diseases related to the modification of an innate and/or acquired immunity by increasing the production of antimicrobial peptides, preferably hBD-2 without inducing inflammatory reactions, irritation or intolerance. Said compound can also comprise a peptidic avocado extract and/or a peptidic lupin extract.

The invention concerns a natural vegetable oil selected among palm oil, corn germ oil, sunflower oil and canola oil, concentrated in unsaponifiable matters, such that said oil unsaponifiable matter content is 3 to 15% m/m. Said concentrated natural vegetable oil constitutes a novel food ingredient enriched in particular in vitamin E and phytosterol, useful as favored food source in vitamin E and phytosterol, meeting recommended daily intake.

Natural vegetable oil concentrated in unsaponifiable matters as food ingredient

The invention relates to the use of one or several synthetic or natural furan alkyls for cosmetically treating cellulite. Said furan alkyls preferably correspond to formula (I), wherein identical or different R, R, Ret Rare independently of each other a hydrogen atom, a C-Calkyl radical, C-Calcenyl radical or a C-Calcynyl radical, preferably C-C, wherein said alkyl, alcenyl and alcynyl radicals are substitutable and R, R, Rare preferably a hydrogen atom. 

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Versailles, France

Antoine Piccirilli