Sanofi

Sanofi-aventis

Evotec International Gmbh

Antoine Alam

Gary Mccort

Olivier Duclos

Francoise Bono

Isabelle Blanc

Sandrine Biscarrat

Françoise Bono

Oliver Duclos

Gary Mc Cort

The present invention relates to novel interferon-associated antigen binding proteins as well as nucleic acids, vectors and vector systems encoding such interferon-associated antigen binding proteins. The present invention also relates to compositions comprising such interferon-associated antigen binding proteins, nucleic acids, vectors and vector systems. The novel interferon-associated antigen binding proteins afford beneficial improvements over the current state of the art, for example inthat they effectively disrupt viral replication and thereby reduce HBV viral load. Thus, the present invention also provides medical uses of such interferon-associated antigen binding proteins, nucleic acids, vectors, vector systems and compositions, e.g., in the treatment of hepatitis B virus (HBV) infection and/or for decreasing one or more symptoms of HBV infection in a subject. The present invention further provides host cells comprising such nucleic acids, vectors and vector systems as well as methods of making the interferon-associated antigen binding proteins according to the invention using said host cells.

Interferon-associated antigen binding proteins and uses thereof

This invention is related to the use of inhibitors of vascular endothelial growth factor receptor 3 for treating hepatocellular carcinoma.

Use of VEGFR-3 inhibitors for treating hepatocellular carcinoma

The disclosure relates to method of treating a disease in which VEGFR-3 is involved, comprising administering a therapeutically effective amount of a compound of the formula wherein R, R, R, and Rare as defined in the disclosure, to compositions containing them, to processes for preparing them, and to their use in therapeutics.

Derivatives of 7 alkynyl-1,8 naphthyridones, preparation method thereof and use of same in therapeutics

The disclosure relates to 7-alkynyl-1,8-naphthyridones of formula (I): wherein R, R, R, and Rare as defined in the disclosure, to compositions containing them, to processes for preparing them, and to their use in therapeutics.

Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics

The disclosure relates to compounds of formula (I): wherein R, R, R, and Rare as defined in the disclosure, to compositions containing them, to processes for preparing them, and to their use in therapeutics.

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Paris, France

Antoine Alam