Novartis Ag

Novartis Inflammasome Research, Inc.

Anthony William Opipari, Jr

Shomir Ghosh

Gary D Glick

Dong-Ming Shen

William R Roush

David Guenther Winkler

Shankar Venkatraman

Jason David Katz

Luigi Franchi

Hans Martin Seidel

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured:

Compounds and compositions for treating conditions associated with NLRP activity

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured. The variables shown in Formula AA are as defined in the claims. The compounds of formula AA are NLRP3 activity modulators and, as such, can be used in the treatment of metabolic disorders (e.g. Type 2 diabetes, atherosclerosis, obesity or gout), a disease of the central nervous system (e.g. Alzheimer's disease, multiple sclerosis, Amyotrophic Lateral Sclerosis or Parkinson's disease), lung disease (e.g. asthma, COPD or pulmonary idiopathic fibrosis), liver disease (e.g. NASH syndrome, viral hepatitis or cirrhosis), pancreatic disease (e.g. acute pancreatitis or chronic pancreatitis), kidney disease (e.g. acute kidney injury or chronic kidney injury), intestinal disease (e.g. Crohn's disease or Ulcerative Colitis), skin disease (e.g. psoriasis), musculoskeletal disease (e.g. scleroderma), a vessel disorder (e.g. giant cell arteritis), a disorder of the bones (e.g. osteoarthritis, osteoporosis or osteopetrosis disorders), eye disease (e.g. glaucoma or macular degeneration), a disease caused by viral infection (e.g. HIV or AIDS), an autoimmune disease (e.g. Rheumatoid Arthritis, Systemic Lupus Erythematosus or Autoimmune Thyroiditis), cancer or aging. 

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: 

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Dexter, MI, United States of America

Anthony William Opipari, Jr