Pharmacia & Upjohn Company

Anthony W Yem

Martin R Deibel, Jr

Vincent E Groppi, Jr

Mark L Wolfe

Cindy L Wolfe

This invention discloses novel forms of catalytic macro molecules that are related to cdc25B, a cell cycle specific phosphatase. These special domains of cdc25B, special fusions with GST, and unique peptides and proteins, their utility, and the method of making them are all described.

Catalytic macro molecules having cdc25B like activity

This invention describes the isolation and identification of a new protein, p56, useful for the identification of drugs that will selectively open or close K channels. The protein p56 has a molecular weight of about 56,000 daltons and the N-terminal peptide sequence is: Glu-Pro-Arg-Ala-Pro-Pro-Glu-Lys-Ile-Ala-Ile-Val-Gly-Ala-Gly-Ile.

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Kalamazoo, MI, United States of America

Anthony W Yem