Oklahoma State University

Anthony W Confer

Sahlu Ayalew

George L Murphy

Karamjeet Pandher

Vaccine preparations for the prevention and treatment of bovine respiratory disease (BRD) and, in particular, its most severe form, termed 'shipping fever', are provided. The preparations comprise chimeric proteins comprising immunodominant epitopes of recombinantouter membrane protein PlpE, and immunodominant epitopes of recombinantleukotoxin.

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Vaccines and methods againstinfections in cattle. The vaccine compositions include a recombinant outer membrane protein ofdesignated PlpE and/or subunits thereof, alone or in combination with other antigenic components, and a carrier or diluent. The methods involve administering an effective immunizing amount of the vaccines to susceptible bovine.

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Stillwater, OK, United States of America

Anthony W Confer