Ludwig Institute for Cancer Research Limited

Anthony W Burgess

Lloyd J Old

Gerd J Ritter

Richard John Simpson

Sydney Welt

Edouard Collins Nice

Hong Ji

Sara J White

Cameron Johnstone

Joan K Heath

R L Moritz

R H Whitehead

Hui-Hua Zhang

B Catimel

This invention relates to isolated protein and to peptides which are found on the surface of colon cells and colon cancer cells, as well as to nucleic acid molecules encoding said protein and peptides. The protein and peptides bind to tumor-associated antibodies, such as mAb A33. The monomeric protein has a molecular weight of about 43 kD as determined by SDS gel electrophoresis under non-reducing conditions. In addition, this invention relates to the use of said nucleic acid molecules, protein, in monomeric or multimeric form, and to antibodies to said peptides in diagnostic, screening and therapeutic methods. This invention further relates to antibodies specific for said protein, in monomeric or multimeric form, and to antibodies to said peptides.

Isolated protein which binds to A33 antibody, and peptides corresponding

The invention describes a colonic crypt cell stimulating mitogen, and conditioned medium containing it. In particular, cell line LIM 2537 is described which, when cultivated in medium, secretes a mitogen which stimulates the proliferation o colonic crypt cells. Applications of the conditioned medium and the cell line are also described.

Conditioned medium useful for sustaining growth of colonic crypt cells

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Victoria, Australia

Anthony W Burgess