Entremed, Inc.

Children's Medical Center Corporation

Miikana Therapeutics, Inc.

Celgene Corporation

Emergent Virology LLC

Anthony Treston

Jamshed H Shah

Gregory E Agoston

Theresa Marie LaVallee

Victor S Pribluda

Kimberly A Hunsucker

Robert J D'Amato

Glenn M Swartz

John Rougas

Barry P Conner

John S Ward

Xiao-Yi Xiao

Shawn J Green

Mark R Bray

Lita Suwandi

Victor Pribdula

Dinish V Patel

Kelly Lyn Warfield

Urban Ramstedt

Christopher J Herbstritt

Xiaoguo H Zhan

Robert J D'amato

Victor Pribluda

Formula IA, and their use for treating viral infections. 

Iminosugars useful for the treatment of viral diseases

Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formulae: wherein Ris selected from &#x2014;OCH, &#x2014;OCHCHor &#x2014;CCCH; and Z is selected from &#x3e;C(H)&#x2014;OH, &#x3e;C(H)&#x2014;O-alkyl, &#x3e;C(H)&#x2014;O-sulfamate, where alkyl is a linear, branched and/or cyclic hydrocarbon chain comprising 1 to 10 carbons.

Methods of treating disease states using antiangiogenic agents

The invention provides new and useful analogs of 4-amino-thalidomide. These analogs include S(&#x2212;)-4-amino-thalidomide and R(+)-4-amino-thalidomide. The invention also provides processes for making these analogs. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering these compounds.

Synthesis of 4-amino-thalidomide enantiomers

Disclosed are protein kinase inhibitors, compositions comprising such inhibitors, and methods of use thereof. More particularly, disclosed are inhibitors of Aurora A (Aurora-2) protein kinase. Also disclosed are methods of treating diseases associated with protein kinases, especially diseases associated with Aurora-2, such as cancer.

Method of treating disease states using substituted pyrazole compounds

Method of synthesis of 4-amino-thalidomide enantiomers

Substituted pyrazole compounds

Antiangiogenic agents

Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification.

Estradiol derivatives and pharmaceutical compositions using same

2-methoxyestradiol having greater than 98% purity is obtained by synthetic or purification methods. This highly pure 2-methoxy estradiol, lacking estrogenic components, is particularly suitable for clinical use in humans. The purification methods of the invention involve the use of liquid-solid chromatography (LSC) to separate 2-ME2 from other compounds. The chromatographic media is preferably silica. The solvent system comprises a non-polar solvent, such as chloroform, and a polar solvent, such as methanol.

Methods of using 2-methoxyestradiol of high purity

The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, nitrogen-substituted thalidomide analogs and di-substituted thalidomide analogs have been shown to inhibit angiogenesis. Importantly, these compounds can be administered orally.

Use of nitrogen substituted thalidomide analogs for the treatment of macular degenerator

Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula: wherein the variables are defined in the specification.

Compositions comprising purified 2-methoxyestradiol and methods of producing same

Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula:wherein the variables are defined in the specification.

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Rockville, MD, United States of America

Anthony Treston