University Health Network

Other

Dartmouth College

Anthony Taywon Kim

Brian Campbell Wilson

Keith Douglas Paulsen

David W Roberts

Pablo A Valdes

Harry Easton

Alexander W Lightstone

Ian Parkinson

Mark Ruschin

David Beachey

Keith D Paulsen

Methods for quantifying fluorescence and optical properties in a turbid medium such as tissue. Devices and systems suitable for the methods are also disclosed.

Device, system and method for quantifying fluorescence and optical properties

Methods, devices and systems for quantifying fluorescence and optical properties in a turbid medium such as tissue are disclosed. One of the methods comprises: providing fluorescence emission and reflectance wavelengths detected from a target surface where each of the detected wavelengths is associated with a respective known distance between a respective excitation source giving rise to the respective detected wavelength and a detector detecting the respective detected wavelength; and calculating the optical properties based on the detected wavelengths and the respective known distances. The known distances may be predetermined to enable calculation of a desired range of values for the optical properties. The calculation of the optical properties may be based on a model of light interaction with the turbid medium where the model limits a range of calculated values for the optical properties.

An optical spectroscopy probe for providing optical spectroscopy guidance of a mechanical biopsy procedure, and a tissue biopsy device including an optical spectroscopy probe. The optical spectroscopy probe is positionable in a lumen of a mechanical biopsy device. The probe may enable optical spectroscopy guidance in biopsy procedures, include brain biopsy procedures.

Biopsy device with integrated optical spectroscopy guidance

A dosimeter that is configured to assist with patient-specific quality assurance ('QA') in arc-based radiotherapy, such as stereotactic radiotherapy, is provided. The dosimeter facilitates acquiring multiple different dosimetric measurements simultaneously. For instance, the dosimeter can be configured to acquire dosimetric measurements from multiple different modalities, including gel dosimetry and film dosimetry, and is configured for simultaneous use with a diode-array QA phantom.

Multi-modality dosimeter for use with arc-based radiotherapy quality assurance phantom

A system for sub-surface fluorescence imaging is provided, the system comprising: an excitation source for selectably emitting light at at least one of at least two excitation wavelengths or wavelength ranges at a target surface; and a light detector for detecting fluorescence emission wavelengths or wavelength ranges from the target surface; wherein at least one of the at least two excitation wavelengths or wavelength ranges causes fluorescing of at least one marker at a sub-surface depth, the emitted light at each of the at least two excitation wavelengths or wavelength ranges having different depths of optical penetration and causing fluorescing at respective different depths. A method for sub-surface fluorescence imaging is also provided, in some cases exemplified by a reconstruction of the sub-surface fluorescence topography.

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Toronto, Canada

Anthony Taywon Kim