New York University

Janssen Biotech, Inc.

Anthony S Lynch

Victor J Torres

Peter T Buckley

Randall J Brezski

William Strohl

Mark Chiu

Brian Whitaker

Keri Dorn

Michelle Kinder

Jinquan Luo

Sheng-Jiun Wu

Thomas J Malia

Nathan Majewski

Jeffrey Fernandez

The disclosure is directed to antibodies that bind tobi-component leukotoxins and/or gamma-hemolysins. Other aspects of the disclosure are directed to pharmaceutical compositions and diagnostic kits containing the leukotoxin and hemolysin antibodies, and therapeutic and diagnostic methods utilizing the leukotoxin and hemolysin antibodies.

Compositions and methods for antibodies targeting staphylococcal leukotoxins

The present disclosure is directed to staphylococcal leukotoxin and hemolysin binding molecules and fusion constructs. The present disclosure is further directed to methods of treating, preventing, and diagnosing staphylococcal infection in a subject using the binding molecules and fusion constructs described herein.

Compositions and methods for anti-staphylococcal biologic agents

The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain is capable of binding to a staphylococcal leukotoxin, preferably LukAB, LukD or LukE. These multi-specific binding compounds have killing activity against staphylococci and, thus, can be used in the treatment and/or amelioration of ainfection, including methicillin-resistant

Compositions and methods for phagocyte delivery of anti-staphylococcal agents

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Spring House, PA, United States of America

Anthony S Lynch