Central Research Laboratories Limited

Astrazeneca Ab

British Nuclear Fuels Plc

Anthony Robert Corless

John Robert Dodgson

John Edward Andrew Shaw

Alastair Sibbald

Monica Backes

Andrew J Garman

Michael Jonathan Harper

Chris Turner

Christopher M Turner

David J Scanlon

John Ea Shaw

David Brennan

The microfabricated cell injector having an injection wall and a cell injection needle projecting from the wall for piercing cells suspended in a fluid. The needle is held within a housing defined by the internal surfaces of the microfabricated cell injector. The housing has an inlet for suspended cells to enter and an outlet for cells to exit via the cell injection needle. A cell propulsion device is provided for impelling cells towards the needle such that, in use, cells suspended in the fluid are impelled towards the injection wall by the injection needle.

Microfabricated cell injector

The invention relates to an apparatus for and method of introducing a substance into an object, particularly into a cell or cellular material. In a preferred arrangement apparatus receives the cell and preferably locates it between first and second electrodes and applies a voltage pulse to cause a disruption in the cell wall. This causes the cell to become permeable. The substance may then be introduced, for example under a fluid pressure. Cells may then be inspected and sorted into transfected and non-transfected types. This may be achieved automatically, for example by using electrophoresis.

Apparatus for, and method of, introducing a substance into an object

Apparatus for locating a plurality of articles

Apparatus for dispensing a predetermined volume of a liquid ( ) comprises a reservoir ( ) for the liquid, a channel ( ) provided with an outlet ( ) for conveying the liquid ( ) from the reservoir to the outlet, and means for generating a pulse of gas. The apparatus is arranged such that the flow of gas causes a predetermined volume of liquid to be ejected from the outlet. The outlet comprises a pair of openings in the channel which face one another, the liquid being retained between the openings by surface tension in the absence of a flow of gas. The gas flow is directed towards one of said openings in use. The apparatus may be used to dispense volumes of a liquid reagent in the range 1 nl to 2 &mgr;l. The apparatus avoids contamination of the liquid, and dispensing head construction allows devices to be low cost disposable units. The apparatus is less sensitive to liquid viscosity than existing devices.

Apparatus for dispensing a predetermined volume of a liquid

Apparatus for carrying out a process between first and second immiscible fluids, comprises first and second channels defining flow paths, for permitting fluid flow of respective first and second immiscible fluids therethrough. Portions of the flow paths are disposed close to, or adjacent to, one another and communicate with one another to define a region in which, in use, a stable interface between the fluids is formed. One, or more, dimensions of the region are varied along the length of the interface in a direction of fluid flow to compensate for variation in the properties of the fluids during the carrying out of the process and thereby maintain stability of the interface.

Method and apparatus for diffusive transfer between immiscible fluids

Apparatus comprising a micro engineered structure and a capillary or other tube and a method for connecting the tube to the structure. The micro engineered structure is composed of at least one substrate,in which fluid flow channels,are formed, connecting to an aperture,into which the tube,is inserted. A sealant material is flowed into the aperture around the tube and then hardened in order to seal the tube within the aperture.

Method of making a fluid connection

Access control system

Growing community of inventors

Ash, United Kingdom

Anthony Robert Corless