Access Closure, Inc.

Monolith Materials, Inc.

Anthony P Spizuoco

Florencia Lim

Andy H Uchida

Scott Robert Sershen

Kevin To

Alexander F Hoermann

Ned J Hardman

Dylan Laidlaw

Aaron S Hampton

Christopher E Mesrobian

Brian R Allison

A sealant is provided for sealing a puncture through tissue that includes an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section fused to and extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The second section may be formed from a solid mass of non-freeze-dried, non-crosslinked hydrogel precursors, the precursors remaining in an unreactive state until exposed to an aqueous physiological, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.

Apparatus and methods for sealing a vascular puncture

The present disclosure provides, for example, systems and methods for generating carbon particles. Carbon particles may have a total content of polycyclic aromatic hydrocarbons of less than or equal to about 0.5 parts per million, a content of benzo[a]pyrene of less than or equal to about 5 parts per billion, and a water spreading pressure that is less than about 5 mJ/m. A carbon particle among the carbon particles may comprise less than about 0.3% sulfur by weight or less than or equal to about 0.03% ash by weight.

Carbon particles having specific contents of polycylic aromatic hydrocarbon and benzo[a]pyrene

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San Francisco, CA, United States of America

Anthony P Spizuoco