Pfizer Corporation

Anthony P Ricketts

Bruce A Hay

Bridget M Cole

Patrick Robert Verhoest

Adam Matthew Gilbert

Rayomand Jal Unwalla

Edmund Lee Ellsworth

Kristin M Lundy

James Thomas Anderson

Nigel A Evans

Eugene Lvovich Piatnitski Chekler

Jean-Pierre Pelletier

Bruce Kipp Erickson

David P Thompson

Carolyn R Kilroy

Eugene Lvovich Chekler

The present invention relates to a compound of Formula 1, 2 or 3: wherein A is N or &#x2014;CR&#x2014;, where Ris hydrogen, C-Clinear or branched chain alkyl, etc., Z is &#x2014;CR&#x2014;, or, &#x2014;N&#x2014;, where Ris hydrogen, C-Clinear or branched chain alkyl, etc.; Ris hydrogen, C-Clinear or branched chain alkyl, etc.; Rare independently hydrogen or C-Clinear or branched chain alkyl; Rand Rare independently hydrogen, C-Clinear or branched chain alkyl, etc.; Rand Rare independently hydrogen or C-Clinear or branched chain alkyl, etc.; Ris hydrogen, C-Clinear or branched chain alkyl, etc.; Rand Rare independently hydrogen or C-Clinear or branched chain alkyl, etc.; Q is &#x2014;CO&#x2014;, &#x2014;(CH)&#x2014;, &#x2014;(CHR)&#x2014;, or &#x2014;(CRR)&#x2014;, where Rand Rare independently C-Clinear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where q is 0, 1, 2, or 3; and, where n is 0, 1, 2, 3, 4 or 5; or, a pharmaceutically acceptable salt thereof, to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.

Selective androgen receptor modulators

Somatostatin antagonists and agonists that act at the SST subtype 2 receptor

Treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in mammals using carprofen and derivatives

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Stonington, CT, United States of America

Anthony P Ricketts