Massachusetts Eye and Ear Infirmary

Children's Medical Center Corporation

The Charles Stark Draper Laboratory, Inc.

Anthony P Adamis

Joan W Miller

Evangelos S Gragoudas

Eirini Iliaki

Jeffrey T Borenstein

Raanan A Miller

Mark Joseph Mescher

Mitchell L Hansberry

Christopher E Dubé

Marcie G Weinstein

The invention includes a method of treating an intraocular disorder in a mammal, the method comprising administering to the mammal a Very Late Antigen-4 (VLA-4) antagonist for the treatment of selected ocular disorders.

Treatment of ocular disorders

The invention provides a miniaturized, implantable drug delivery device and a method of delivering over a prolonged period of time one or more drugs using such a device. The drug delivery device can be adapted for attachment to the outer surface of an eye. Once attached to the outer surface of an eye, the device can deliver one or more drugs directly into the eye for preventing or ameliorating the symptoms of a particular ocular disorder.

Implantable drug delivery device and use thereof

The claimed invention relates to methods of treating retinopathy, retinal ischemia and/or retinal edema comprising administering an integrin antagonist, a leukocyte adhesion inducing cytokine antagonist, a selectin antagonist or adhesion molecule antagonist.

Prevention and treatment for retinal ischemia and edema

The present invention relates to methods of treating retinopathy, retinal ischemia and/or retinal edema comprising administering an integrin or integrin subunit antagonist, leukocyte adhesion-inducing cytokine antagonist or growth factor antagonist, a selectin antagonist or adhesion molecule antagonist.

Prevention and treatment of retinal ischemia and edema

Growing community of inventors

Jamaica Plain, MA, United States of America

Anthony P Adamis