Merck Frosst Canada & Co.

Anthony Mastracchio

Yves Girard

Daniel Dube

Michel Gallant

Patrick Lacombe

Denis Deschenes

Dwight MacDonald

Helene Perrier

8-arylquinolines of formula (I) wherein the aryl group at the 8-position contains a meta two atom bridge to an optionally substituted phenyl or pyridyl group, are PDE4 inhibitors useful to treat asthma, chronic bronchitis, chronic obstructive pulmonary disease, arthritis, respiratory distress syndrome, allergic rhinitis, neurogenic inflammation, pain, rheumatoid arthritis, and other diseases. R-Rand Ar are as in claim

Substituted 8-arylquinolune PDE4 inhibitors

Novel substituted 8-arylquinolines, wherein the aryl group at the 8-position contains a substituent substituted-alkenyl group, are PDE4 inhibitors.

Substituted 8-arylquinoline phosphodiesterase-4 inhibitors

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Linden, NJ, United States of America

Anthony Mastracchio