Smith Kline & French Laboratories Limited

Anthony Maitland Roe

Robert A Slater

William J Coates

Edwin Michael Taylor

Stephen P Breukelman

Bernard Loev

George D Meakins

This invention relates to (isopropyl and tertiary butyl-amino-2-hydroxypropoxy)phenyl-3[2H]-pyridazinones which have .beta.-adrenoceptor antagonist activity.

5-phenyl-3[2H]-pyridazinone derivatives

Pharmaceutical compositions having .beta.-adrenoceptor antagonist

Substituted derivatives of 3-chloro-6-phenylpyridazine which are useful intermediates in the preparation of substituted phenylhydrazinopyridazines which have .beta.-adrenergic blocking and vasodilator activity.

3-Chloro-6-phenylpyridazine compounds

Substituted phenyl pyridazinethiones which are useful intermediates in the preparation of substituted phenylhydrazinopyridazines which have .beta.-adrenergic blocking and vasodilator activity.

Pyridazinethiones

The compounds are substituted hydrazinophthalazines which are active as .beta.-adrenergic blocking agents and as vasodilators. A specific compound of the invention is 5-(3-t-butylamino-2-hydroxypropoxy)-1-hydrazinophthalazine.

(3-Alkylamino-2-hydroxypropoxy)-1-hydrazinophthalazines

The compounds are 3-(3-(3-substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino pyridazines which have .beta.-adrenergic blocking and vasodilator activity.

3-(3-(3-Substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino

The compounds are 3-((3-substituted amino-2-hydroxypropoxy)-phenyl)-6-hydrazino pyridazines which have .beta.-adrenergic blocking and vasodilator activity.

3-Substituted-phenyl-6-hydrazine pyridazines

The compounds are 6-(3-substituted amino-2-hydroxypropoxyaryl)-4,5-dihydro-3(2H)-pyridazinones which are .beta.-adrenergic blocking agents.

Pharmaceutical compositions and methods of inhibiting .beta.-adrenergic

The compounds are 1,4-dihydropyridines having antihypertensive activity. A particular compound of this invention is 1,4-dihydro-2,6-dimethyl-4-(2-trifluoromethylphenyl)pyridine-3,5-dicarboxy lic acid bis-(2-hydroxyethyl)ester.

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Hatfield, United Kingdom

Anthony Maitland Roe