Spansion Llc.

Corium International, Inc.

Leland Stanford Junior University

Cypress Semiconductor Corporation

Corium Corporation

Poincare Systems, Inc.

Lam Research Corporation

Corium Pharma Solutions, Inc.

Poinare Systems, Inc.

Anthony Le

Parminder Singh

Robert Wade Worsham

Joseph Creagan Trautman

Ashutosh Shastry

Douglas Joseph Scott Bourne

Doug Bourne

Nicholas John Richardi

Clifford Alan Zitlaw

Jackson Huang

Tuqiang Q Ni

Cliff Zitlaw

Chung-Ho Huang

Kevin Widmer

Tuan Ngo

Farro F Kaveh

Connie Lam

Tina M Cowan

Clifford Jeffrey Lin

Malcolm Kitchen

Steven Salkow

Disclosed herein are methods of analyzing a biological sample comprising: separating components of the biological sample via reversed-phase (RP) chromatography to obtain an elute; subjecting the elute to separation via ion-exchange (IEX) chromatography or mixed-mode IEX chromatography; and detecting the separated compounds to determine the components of the biological sample. Also disclosed are devices comprising a reversed-phase (RP) chromatography column in communication with an ion-exchange (IEX) chromatography column or mixed-mode IEX chromatography column, wherein there is no switching valve between the columns.

Metabolic profiling by reverse-phase/ion-exchange mass spectrometry

An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.

Applicators for microneedles

Applicators for a microprojection array and methods of using the applicators are described.

Microprojection applicators and methods of use

An imaging device includes a grin lens having a proximal end and a distal end, wherein the grin lens is made from a polymeric material, an optical fiber having a distal end coupled to the proximal end of the grin lens, and a beam director coupled to the distal end of the grin lens, wherein the beam director is configured to direct light at an angle relative to a longitudinal axis of the optical fiber.

Grin lens and methods of making the same

Applicators for a microprojection array capable of multiple impacts and methods of using the applicators are described.

Multiple impact microprojection applicators and methods of use

A method of making an axicon includes providing a structure having an axicon-shape cavity, the cavity having a first end and a second end, the first end of the cavity having a cross sectional dimension that is smaller than the second end, placing a polymeric substance into the axicon-shape cavity, and forming an axicon using the polymeric substance.

Axicons and methods of making the same

A memory subsystem is disclosed. The memory subsystem includes a serial peripheral interface (SPI) double data rate (DDR) volatile memory component, a serial peripheral interface (SPI) double data rate (DDR) non-volatile memory component coupled to the serial peripheral interface (SPI) double data rate (DDR) volatile memory component and a serial peripheral interface (SPI) double data rate (DDR) interface. The serial peripheral interface (SPI) double data rate (DDR) interface accesses the serial peripheral interface (SPI) double data rate (DDR) volatile memory component and the serial peripheral interface (SPI) double data rate (DDR) non-volatile memory component where data is accessed on leading and falling edges of a clock signal.

High speed serial peripheral interface memory subsystem

A medical device includes an elongate member having a proximal end, a distal end, a body extending between the proximal end and the distal end, and a lumen located within the body, and a rotor rotatably supported in the lumen, the rotor having an opening for allowing light to pass theretherough, wherein the rotor is rotatable about an axis that extends through the opening, wherein the elongate member further has a region for allowing an output light to exit therethrough.

Medical devices with internal motors

A memory device is provided. The memory device includes a preamble memory and a memory controller. The preamble memory is arranged to store a read preamble such that the read preamble includes a training pattern that is suitable for aligning a capture point for read data. Further, the training pattern is programmable such that the training pattern can be altered at least once subsequent to manufacture of the preamble memory. In response to a read command, the memory controller provides the read preamble stored in the preamble memory, as well as the read data.

Apparatus and method for programmable read preamble with training pattern

The present invention provides liquid chromatography-mass spectrometry methods and kits for the specific, sensitive and rapid detection as well as quantitation of free amino acids in samples following High Pressure Liquid Chromatography (HPLC) separation.

Liquid chromatography-mass spectrometry methods for multiplexed detection and quantitation of free amino acids

The subject systems and/or methods relate to a high speed memory device that enables a preamble pattern to be updated after manufacture. A high speed memory device can include a FLASH module and a RAM module. The FLASH module can include an initial preamble pattern, wherein the initial preamble pattern is loaded during a power-up of the high speed memory. The RAM module can include a default preamble pattern, wherein the default preamble pattern is loaded after the power-up of the high speed memory. The initial preamble pattern or the default preamble pattern can be defined by a manufacture of the high speed memory or an OEM of the high speed memory. Additionally, the initial preamble pattern or the default preamble pattern can be updated with a customized preamble pattern based upon a target environment.

High speed memory having a programmable read preamble

Systems and methods of detecting an auto-boot mode and booting data from a serial peripheral interface to a processor without the need of a read instruction utilizing a serial peripheral interface having an auto-boot mode detector are provided. In one embodiment, a serial peripheral interface comprises a serial processing component configured to serially communicate data between the processor and at least two peripherals, and an auto-boot component operably coupled to the serial processing component, comprising an auto-boot mode detector configured to determine whether a boot mode exists based on detecting whether serial input data is received during a predetermined wait state, and configured to selectively boot data to a start address associated with the processor based on the boot mode determination.

Growing community of inventors

San Jose, CA, United States of America

Anthony Le