Other

Akzo Nobel N.v.

University System of Maryland

Anthony L Devico

Mangalasseril G Sarngadharan

Ranajit Pal

Robert C Gallo

Alfredo Garzino-Demo

George K Lewis

Timothy R Fouts

Robert G Tuskan

Jennifer M Burns

The present invention relates to compositions and methods of using same to direct an immune response thereby enhancing the efficacy of an antigen containing vaccine by combining a chemokine in conjunction with the vaccine, wherein the choice of the chemokine directs the immune response in either the Th1 or Th2 direction.

Directional induction of immune response by co-administration of antigens with chemokines

A vaccine and a method of raising neutralizing antibodies against HIV infection. The vaccine comprises a complex of gp120 covalently bonded to CD4 or to succinyl concanavalin A. Also disclosed are immunological tests using the complex or antibody thereto for detection of HIV infection.

HIV immunogenic complexes comprising GP120 covalently bound to CD4 or concanavalin A

The present invention provides therapeutic compositions of receptor ligand-containing antagonist complexes and methods of using them to treat diseases, disorders or conditions associated with the function or aberrant function of a cell surface receptor.

Chemokine&mdash;glycosaminoglycan complexes and their use in treating or preventing receptor mediated diseases

The present invention is directed to a method of raising neutralizing antibodies against HIV using a complex of gp120 covalently bonded to CD4 or a complex of gp120 covalently bonded to succinyl concanavalin A.

Method of raising neutralizing antibodies against HIV

The present invention relates to therapeutic compositions and methods for treating and preventing infection by an immunodeficiency virus, particularly HIV infection, using chemokine proteins, nucleic acids and/or derivatives or analogues thereof.

Chemokines that inhibit immunodeficiency virus infection and methods based thereon

Neutralizing antibodies against HIV infection are provided. The antibodies are reactive with cryptic epitopes on gp120 and/or CD4 induced by the formation of immunogenic complexes comprising gp120 covalently bonded to CD4 or to succinyl concanvalin A.

Neutralizing antibodies against HIV infection

HIV immunogenic complexes

A vaccine and a method of raising neutralizing antibodies against HIV infection. The vaccine comprises a complex of gp120 bonded covalently to CD4 or to succinyl concanavalin A.

Growing community of inventors

Alexandria, VA, United States of America

Anthony L Devico