Grifols Worldwide Operations Limited

Grifols Therapeutics Inc.

Anthony Klos

Thomas P Zimmerman

James Rebbeor

Charles Miller

Eric Allgaier

Kevin Wee

Michelle StPeter

Kelly Glancy

Jianxin Guo

Deborah Barnette

Mark Cornell Manning

Bret Coldren

Compositions include highly concentrated Alpha-1 Proteinase Inhibitor (A1PI) in a concentration greater than or equal to 100 mg/ml. Pharmaceutical compositions can be prepared from these compositions. The pharmaceutical compositions can be suitable for subcutaneous administration. The highly concentrated A1PI solutions can be obtained by single-pass tangential flow filtration (SPTFF).

Composition comprising highly-concentrated Alpha1 proteinase inhibitor and method for obtaining thereof

Compositions include highly-concentrated Alpha-1 Proteinase Inhibitor (A1PI) in a concentration greater than or equal to 100 mg/ml. Pharmaceutical compositions can be prepared from these compositions. The pharmaceutical compositions can be suitable for subcutaneous administration. The highly-concentrated A1PI solutions can be obtained by single-pass tangential flow filtration (SPTFF).

Composition comprising highly-concentrated &#x3b1;1 proteinase inhibitor and method for obtaining thereof

Composition comprising highly-concentrated ALPHA1 proteinase inhibitor and method for obtaining thereof

The present invention provides compositions comprising API and at least one amino acid, in particular a liquid API formulation comprising amino acids, and methods and kits related thereto. These amino acids when incorporated into the API composition afford stability to the API formulation.

Composition, method, and kit for alpha-1 proteinase inhibitor

Method for lyophilization is provided, in particular methods for lyophilization of formulations comprising AT III. Also provided are compositions prepared by therefrom. Also provided are kits comprising the compositions and/or lyophilized products.

Lyophilization methods, compositions, and kits

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Raleigh, NC, United States of America

Anthony Klos