Massachusetts Institute of Technology

Anthony James Martorell

Li-Huei Tsai

Emery Neal Brown

Chinnakkaruppan Adaikkan

Hannah Iaccarino

Ho-Jun Suk

Edward Stuart Boyden

Ed Boyden

A method includes administering a non-invasive stimulus to a subject having a frequency of about 35 Hz to about 45 Hz to induce synchronized gamma oscillations in at least one brain region of the subject.

Methods and devices for providing a stimulus to a subject to induce gamma oscillations

Devices, systems, and methods for a treating dementia or Alzheimer's disease in a subject in need thereof. In one example, combined auditory and visual stimuli having a frequency of about 20 Hz to about 60 Hz, and more specifically about 40 Hz, are non-invasively delivered to the subject to induce synchronized gamma oscillations in at least one brain region of the subject. In particular, pursuant to various treatment and exposure protocols, combined auditory and visual stimulation (as opposed to auditory or visual stimulation alone) promotes a microglia response in the medial prefrontal cortex (mPFC). More generally, combined auditory and visual stimulation induces an extended microglia clustering response in the auditory cortex, the visual cortex, and the mPFC.

Systems and methods for preventing, mitigating, and/or treating dementia

The present disclosure provides systems and methods for at least one of preventing, reducing, and treating a level of or change in at least one of amyloid-&#x3b2; (A&#x3b2;) peptide, C-terminal fragment-&#x3b2; (&#x3b2;-CTF), &#x3b2;-secretase (BACE1), &#x3b3;-secretase, neuroinflammation, and/or dementia (e.g., Alzheimer's disease or age-related decline) in a subject by inducing synchronized gamma oscillations in the brain of the subject using, for example, a stimulus-emitting device to emit a stimulus (e.g., light, sound, and/or haptic) at a frequency (e.g., about 40 Hz) that synchronously activates in vivo a specific cell type (e.g., fast-spiking-parvalbumin (FS-PV) immunoreactive interneurons) and/or brain region (e.g., a sensory cortex and/or hippocampus) of the subject.

Systems and methods for treating dementia

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Cambridge, MA, United States of America

Anthony James Martorell