Oriel Therapeutics, Inc.

The University of North Carolina at Chapel Hill

Nobex Corporation

Astartein, LLC

Biocon Limited

Parion Sciences, Inc.

Anthony James Hickey

Timothy M Crowder

Jeffrey Alan Warden

Nnochiri Ekwuribe

Richard Soltero

Li Li Bovet

Bruce Rehlaender

James R Meckstroth

Hugh D C Smyth

Keith Johnson

Bruce S Ferris

William Myles Riley

Jay Kinsley Fording

Michael Duane Garten

Sean Anderson

Paul Gilbert Rockwell

Foyeke Opawale

Vanessa Boekestein

Mark Ennis Ketner

Balasingam Radhakrishan

Michael Ross Johnson

Richard C Boucher

James B Fink

William Robert Thelin

Tomas Navratil

Mark Jeffrey Edhouse

Brian Button

Philip Jerome Driver

Stuart Robert Abercrombie

Paul Boucher

Nicholas O Heijne

Donal Joseph Taylor

Jonathan Hugh Wilkins

Martin J Telko

Sorin M Mitran

Brian M Button

A facemask includes a facemask body, a plurality of electrical contacts and a control circuit. The facemask body has an end including an opening and a skin contact perimeter extending along a periphery of the opening, with the skin contact perimeter configured to sealingly engage with a user's face. Each electrical contact is disposed at a respective region of the skin contact perimeter, and each electrical contact is configured to sense when the respective region of the skin contact perimeter is sealingly engaged with a user's face. The control circuit is disposed on the facemask body, and the control circuit is configured to receive a signal from each electrical contact when the respective region of the skin contact perimeter is sealingly engaged with a user's face and to initiate output of an audible stimulus and/or a visual stimulus in response to receiving a concurrent signal from all of the plurality of electrical contacts.

Devices, systems and methods for facilitating facemask compliance

Dosing heads for apparatus for dispensing a defined amount of dry powder concurrently to a plurality of spaced apart dose receiving containers include a plurality of spaced apart elongate channels having a channel length with an upper end defining an entry orifice and a lower end defining an exit port. In use, the dosing heads are aligned with a dry powder bed residing above and in communication with the dosing head and at least one vibration source in communication with the dosing head channels configured to controllably apply a vibration flow signal. When the vibration flow signal is applied to the dosing head channels, dry powder from the dry powder bed flows through the elongate channels and out the exit port and when the flow signal is removed, dry powder does not flow through the dosing head elongate channels.

Dosing heads for direct fill dry powder systems configured for on/off controlled flow

Apparatus for dispensing a defined amount of dry powder concurrently to a plurality of spaced apart dose receiving containers include: (a) a dosing head comprising a support body with a plurality of spaced apart elongate channels having a channel length with an upper end defining an entry orifice and a lower end defining an exit port; (b) a dry powder bed residing above and in communication with the dosing head; and (c) at least one vibration source in communication with the dosing head channels configured to controllably apply a vibration flow signal, wherein, when the vibration flow signal is applied to the dosing head channels, dry powder from the dry powder bed flows through the elongate channels and out the exit port and when the flow signal is removed, dry powder does not flow through the dosing head elongate channels.

Direct fill dry powder systems with dosing heads configured for on/off controlled flow

An aerosol preparation assembly includes an entrainment chamber defining an entrainment volume. The entrainment chamber includes a gas inlet port, an aerosol inlet port and an outlet port. The entrainment chamber is configured such that a velocity of a flow of a gas within the entrainment volume is less than a velocity of the flow of the gas within the gas inlet port. The entrainment chamber is configured such that at least a portion of inlet aerosol is entrained into the flow of the gas within the entrainment volume to produce an entrained aerosol flow at the outlet port. The particle selection chamber is configured to receive the entrained aerosol flow and produce an outlet aerosol flow. The particle selection chamber and nozzle are collectively configured such that a volumetric median diameter of the outlet aerosol flow is less than a volumetric median diameter of the inlet aerosol.

Aerosol delivery systems, compositions and methods

Dry powder inhalers include an elongate body and a disk holding a plurality of doses of a dry powder inhalable product. The inhaler also includes a cover member that is pivotably attached to the elongate body so that it remains attached to the body during normal operational periods of use and moves to a first closed position to overlie the inhalation port at the bottom end portion of the body during periods of non-use and moves to a second open position away from the inhalation port during periods of use to allow a user to access the inhalation port.

Dry powder inhalers

Dry powder aerosol generators and related methods are provided. The dry powder aerosol generator includes a dispersion chamber having an internal cavity therein capable of receiving a dry powdered drug. The dispersion chamber includes a dosing port defined therein that is in fluid communication with the internal cavity. A dosing chamber for receiving a test subject is attachable to the dosing port, such that, when an airflow is created within the internal cavity, any dry powdered drug contained therein may fluidize and travel into the dosing chamber to provide opportunity for inhalation of the dry powdered drug by a test subject contained within the dosing chamber.

Dry powder aerosol generator

An apparatus for generating an aerosol of a therapeutic agent and methods of using the same are disclosed. The apparatus comprises a heating element having a surface and a composition coating at least a portion of the heating element surface. The composition comprises a carrier and a therapeutic agent, wherein when the heating element surface is heated to at least the vaporization point of the carrier, the carrier vaporizes and releases the therapeutic agent from the composition as an aerosol. The heating element can be a coiled filament. The therapeutic agent can be a small molecule, a polynucleotide, a polypeptide, or a recombinant virus. The apparatus can be incorporated into a delivery device, such as a metered dose inhaler or an exposure chamber.

Coated filament for evaporation/condensation aerosol generation of therapeutic agents and methods for using

Methods of modulating a characteristic of a pharmaceutical compound spray by acoustic measurement and control of the pharmaceutical spray are disclosed. The methods include analyzing a selected characteristic of a pharmaceutical compound spray utilizing acoustic measurement to develop corresponding acoustic data. The methods further include controlling the selected characteristic by applying acoustic excitation to the pharmaceutical compound spray in accordance with the acoustic data developed.

Methods of acoustic measurement and control of pharmaceutical sprays

Methods, systems, and computer program products flowably process dry powders using a non-linear vibratory signal individualized or customized to a target dry powder undergoing processing to facilitate fluidic flow through a flow channel.

Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders

The present invention includes dry powder inhalers for dispensing and/or holding inhalant formulated dry powder substances and associated fabrication and dispensing methods that can employ an amplitude modulated non-linear signal comprising a plurality of superimposed frequencies, the frequencies corresponding to a priori flow characteristic frequencies of the dry powder being dispensed. The present invention also includes pocket-sized inhalers with an elastomeric flexible pivoting cover.

Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages

Dry powder inhalers with a multi-dose dry powder package for dispensing pharmaceutical grade formulations of inhalable dry powder, include: (a) a blister package comprising a plurality of spaced apart sealed blisters thereon, each blister having a projecting ceiling and a floor defining a blister channel therebetween, the blister channel comprising a dry powder therein; (b) a movable blade cartridge holding a blade at a forward portion thereof; and (c) an extendable mouthpiece attached to the movable blade cartridge. In operation, a user pulls the mouthpiece outward and then pushes the mouthpiece inward to cause the blister package to advance to position a blister in a selected dispensing position in the inhaler and to cause the blade cartridge to move the blade across a blister ceiling held in the dispensing position in the inhaler to thereby open the blister held in the dispensing position.

Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances

Systems for flowably dispensing dry powders include means for generating a first non-linear vibration input signal, the first non-linear input signal comprising a carrier frequency modulated by a plurality of different selected frequencies that correspond to a first dry powder formulation whereby first meted quantities of the first dry powder are serially dispensed to a receiving member. Related devices and computer program products for dispensing dry powders are also described.

Dry powder dose filling systems and related methods

Dry powder blister packages include sealed blisters with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.

Blister packages with frames and associated methods of fabricating dry powder drug containment systems

Growing community of inventors

Chapel Hill, NC, United States of America

Anthony James Hickey