Becton Dickinson and Company Limited

Anthony J Walder

Donald D Solomon

Mark A Crawford

Can B Hu

James M Lambert

Richard W Beck

Gregory J Mann

Timothy Ignatius

A method to render a medical article antithrombogenic and/or anti-infective includes coextruding a base polymer with a hydrophilic laminating polymer having dispersed therein a quarternary salt complexing agent and steeping the extruded article in an aqueous solution of an antithrombogenic and/or anti-infective reagent whereby the reagent is absorbed along with water by the hydrophilic polymer and reacts with the complexing agent.

Method for rendering a substrate surface antithrombogenic and/or

An obturator is provided which allows for placing and withdrawing of a single catheter obturator over an extended period of time so as to allow spaced intervals of use, and non-use of a catheter while in place in the patient's skin, while at the same time doing away with cumbersome, costly and time consuming administration and maintenance of saline and heparin locks. The device feeds the obturator in place for occluding the catheter lumen, when no fluids are being administered to the patient, and then may be retracted to a position allowing fluid feed through a supply tube connection to the catheter. The device includes a coating on the obturator rod which swells in contact with aqueous fluids to seal completely the catheter lumen which coating includes heparin to prevent clotting. Moreover, the entire internal functioning arrangement remains sterile during the entire period of use, thus avoiding infection.

Catheter obturator with automatic feed and control

An obturator is provided which allows for placing and withdrawing of a single catheter obturator over an extended period of time so as to allow speed intervals of use, and non-use of a catheter while in place in the patient's skin, while at the same time doing away with cumbersome, costly and time consuming administration and maintenance of saline and heparin locks. The device feeds the obturator in place for occluding the catheter lumen, when no fluids are being administered to the patient, and then may be retracted to a position allowing fluid feed through a supply tube connection to the catheter. The device includes a coating on the obturator rod which swells in contact with aqueous fluids to seal completely the catheter lumen which coating includes heparin to prevent clotting. Moreover, the entire internal functioning arrangement remains sterile during the entire period of use, thus avoiding infection.

Melt processable polyurethaneureas are prepared from a diisocyanate, a macroglycol, a diol chain extender and a diamine chain extender. Water may be included as a reactant, and the polymer may contain an additive such as a radiopaque material. The invention includes a one-pot bulk polymerization method for preparation of the polymers.

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Franklin, OH, United States of America

Anthony J Walder