Massachusetts Institute of Technology

Malaysian Palm Oil Board

Archer Daniels Midland Company

Phenolaeis Mexico Sapi De Cv

Anthony J Sinskey

ChoKyun Rha

Oliver P Peoples

Ravigadevi Sambanthamurthi

Spiros Jamas

Philip A Lessard

Yew Ai Tan

Laura B Willis

Mohd Basri Wahid

Kalyana Sundram P Manickam

Stephane Guillouet

Donald D Easson, Jr

Paul D Hanke

T G Sambandan

TetsuHisa Nakamura

Sambandan Tg

Avital A Rodal

Maximillian T Follettie

Wolfgang Liebl

Kazuhiko Kurosawa

Pasawadee Pradipasena

Kristi D Snell

Sang Jun Sim

Steven R Tannenbaum

Graham C Walker

Tg Sambandan

Paolo Boccazzi

Tillman U Gerngross

Daniel MacEachran

Scott A Hogan

Stephen B Maul

Jason W Holder

Makoto Yoshihama

William G Shanabruch

Eswara A Rao

Kanji Higashio

Kazuhiro Kurosawa

Donald D Easson Jr

Chokyun Rha

Anastasia Artamonova

Joseph De Angelo

Kevin Ohashi

Tan Yew Ai

Cho Kyun Rha

John A C Archer

Robert P Weinberg

Tan Yew Ai Ai

The invention provides a method for enhancing flavour profile of beverages comprising increasing perceptibility of sweetness, increasing acidity, and decreasing astringent taste in beverages, increasing perceptibility of floral and spice notes by adding an effective flavour enhancing amount of water-soluble Palm Fruit Bioactive complex (wsPFBc/OPP) or their extracts into a beverage is disclosed a composition comprising a beverage and oil palm phenolics (OPP) or their extracts such that the OPP or their extracts modify or alter the fragrance and flavour of the beverage.

Beverage compositions comprising water-soluble palm fruit bioactive complex/oil palm phenolics and palm fruit juice

Present invention discloses an oil palm composition for use in prevention or treatment of Alzheimer's disease. The composition is useful in impeding formation of neurotoxic peptide. Present invention can be used in preparation of a medicament in a therapeutic effective amount for prevention or treatment of Alzheimer's disease and diseases related thereto.

Protective effects of oil palm composition on Alzheimer's disease

Compositions comprising oil palm phenolics and shikimic acid or derivatives thereof and their use in enhancing anti-oxidative and anti-inflammatory properties.

Antioxidant, anti-inflammatory compositions and uses thereof

A composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives extracted from any part of oil palm including but not confined to the vegetation liquor of palm oil milling and palm oil mill effluent, and a method for use in the preparation of a composition containing caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives. The method includes the steps of pre-concentrating an extract containing the caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives and isolating the caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives from said extract by liquid chromatography, wherein the elution activity of said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, with the caffeoylshikimic acids and their derivatives varying depending on the stationary phase and the composition of the mobile phase.

Composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid and their derivatives and method of preparation thereof

The present invention provides compositions and method for production of shikimic acid based on extracts obtained from oil palm-based materials, and more particularly oil palm-based waste materials and by-products. The method includes purifying shikimic acid from extracts comprising oil palm phenolics (OPP).

Compositions comprising shikimic acid obtained from oil palm-based materials

A composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives extracted from any part of oil palm including but not confined to the vegetation liquor of palm oil milling and palm oil mill effluent, and a method for use in the preparation of a composition containing caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives. The method includes the steps of pre-concentrating an extract containing the caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives and isolating said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives from said extract by liquid chromatography, wherein the elution activity of said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives vary depending on the stationary phase and the composition of the mobile phase.

The present invention provides compositions and method for production of shikimic acid based on extracts obtained from oil palm-based materials, and more particularly oil palm based waste materials and by-products. The method includes purifying shikimic acid from extracts comprising oil palm phenolics (OPP).

Compositions comprising shikimic acid obtained from oil palm based materials and method of producing thereof

The embodiments disclosed herein relate to bacterial cell production of triacylglycerides from renewable biomass resources.

Production of triacylglycerides from renewable biomass using oleaginous microorganisms

The invention relates to production of triacylglycerols in cells.

Production of triacylglycerides, fatty acids, and their derivatives

Certain aspects of the invention relate to antibiotics, as well as pharmaceutically acceptable salts, pro-drugs and/or analogs thereof. Another aspect of the invention relates to methods of use of said antibiotics.

Bioactive molecules from co-cultivation of microbes

The present invention relates to a mutated pyruvate carboxylase gene from. The mutant pyruvate carboxylase gene encodes a pyruvate carboxylase enzyme which is resistant to feedback inhibition from aspartic acid. The present invention also relates to a method of replacing the wild-type pyruvate carboxylase gene inwith this feedback-resistant pyruvate carboxylase gene. The present invention further relates to methods of the production of amino acids, preferably lysine, comprising the use of this mutant pyruvate carboxylase enzyme in microorganisms.

Feedback-resistant pyruvate carboxylase gene from corynebacterium

A method for controlling and modifying biopolymer synthesis by manipulation of the genetics and enzymology of synthesis of polyhydroxybutyrate (PHB) and polyhydroxyalkanoate (PHA) polyesters at the molecular level in procaryotic and eukaryotic cells, especially plants. Examples demonstrate the isolation, characterization, and expression of the genes involved in the production of PHB and PHA polymers. Genes encoding the enzymes in the PHB and PHA synthetic pathway (beta-ketothiolase, acetoacetyl-CoA reductase and PHB polymerase or PHA polymerase) fromstrain I-16-M,, andwere identified or isolated and expressed in a non-PHB producing organism,. Specific modifications to the polymers include variation in the chain length of the polymers and incorporation of different monomers into the polymers to produce co-polymers with different physical properties.

Polyhydroxybutyrate polymerase

The present invention relates, in general, to the over-production of L-isoleucine by nonhuman organisms. More specifically, the present invention relates to methods for producing L-isoleucine comprising: (a) growing a transformed nonhuman organism under conditions that provide for synthesis of L-isoleucine, wherein the nonhuman organism comprises one or more copies of a transgene comprising at least one nucleotide sequence encoding catabolic threonine dehydratase; wherein the L-isoleucine is synthesized by the transformed nonhuman organism, the synthesis being greater than that of the corresponding non-transformed nonhuman organism; and (b) recovering the L-isoleucine from the culture medium in which the transformed nonhuman organism was cultured.

Methods for producing L-isoleucine

The present invention concerns an anaplerotic enzyme fromwhich replenishes oxaloacetate consumed during lysine and glutamic acid production in industrial fermentations. In particular, isolated nucleic acid molecules are provided encoding the pyruvate carboxylase protein. Pyruvate carboxylase polypeptides are also provided.

Pyruvate carboxylase from Corynebacterium glutamicum

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Boston, MA, United States of America

Anthony J Sinskey