Depuy Synthes Products, Inc.

Advanced Technologies and Regenerative Medicine, LLC

Ethicon, Gmbh

Omrix Biopharmaceuticals Inc.

Anthony J Kihm

Anna Gosiewska

Alexander M Harmon

Ian Ross Harris

Darin J Messina

Agnieszka Seyda

Sanjay Mistry

Chin-Feng Yi

Sridevi N Dhanaraj

Israel Nur

Liliana Bar

Roberto Meidler

David C Colter

Charito S Buensuceso

Haimanti Dorai

Roee Atlas

Yu Sun

Xiang Yao

Brian C Kramer

Carrie H Fang

Reyna L Favis

Stefanie Rassnick

Christine K Ward

L S Klaudyne Hong

Ziwei Wang

Carri H Fang

Meidler Roberto

Klaudyne L S Hong

Laura J Brown

Klaudyne L Hong

Agneiszka Seyda

David Colter

Charito Buensuceso

Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.

Cartilage and bone repair and regeneration using postpartum-derived cells

Cells derived from postpartum placenta and methods for their isolation are provided by the invention. The invention further provides cultures and compositions of the placenta-derived cells. The placenta-derived cells of the invention have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications.

Postpartum cells derived from placental tissue, and methods of making and using the same

This invention provides for compositions for cryopreservation of human umbilical cord tissue-derived cells. The cryopreservation compositions may comprise: (a) amino acids; (b) vitamins; (c) inorganic salts; and (d) DMSO, sucrose, mannitol, and lactobionic acid. The invention also provides for kits comprising the composition and human umbilical cord tissue-derived cells and methods of cryopreserving the cells, which utilize the compositions.

Composition and methods for cryopreservation of hUTC

The invention relates to methods for detecting allogeneic therapeutic cells (such as human umbilical cord tissue-derived cells (hUTC)) in blood. The methods includes the steps of identifying one or more one or more markers positive for allogeneic therapeutic cells (e.g. hUTC) and one or more markers positive for human peripheral blood mononuclear cells (PBMC); providing a blood sample from a patient that has been treated with allogeneic therapeutic cells (e.g. hUTC), analyzing the sample using an assay method to detect one or more markers positive for PBMC and one or more markers positive for allogeneic therapeutic cells (e.g. hUTC); and distinguishing between the PBMC and one or more markers positive for allogeneic therapeutic cells (e.g. hUTC). In one embodiment, the cells are hUTC and the markers positive of hUTC include CD10 and/or CD13 and the one or more markers positive for PBMC includes CD45.

Detection of human umbilical cord tissue-derived cells

Compositions and methods of using cells derived from umbilical cord tissue to stimulate and support lung tissue angiogenesis, to improve blood flow to lung tissue, to regenerate, repair, and improve lung tissue damaged by lung disease, disorder and/or injury, and to protect lung tissue from damage caused by lung disease, disorder and/or injury in a patient.

Treatment of lung and pulmonary diseases and disorders

Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.

Postpartum cells derived from umbilical cord tissue, and methods of making and using the same

Methods for treating Alzheimer's disease, or the symptoms of Alzheimer's disease, are provided. Some embodiments are to methods for treatment comprising administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells, such as cell derivatives. Some embodiments are to methods for treatment comprising hUTC. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.

hUTC as therapy for Alzheimer's disease

Detection of human umbilical cord tissue derived cells

Compositions and methods of using cells derived from umbilical cord tissue, to stimulate and support angiogenesis, to improve blood flow, to regenerate, repair, and improve skeletal muscle damaged by a peripheral ischemic event, and to protect skeletal muscle from ischemic damage in peripheral vascular disease patients are disclosed. In particular, methods of treating a patient having a peripheral vascular disease by systemic administration of umbilical derived cells are disclosed.

Treatment of peripheral vascular disease using umbilical cord tissue-derived cells

Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.

Regeneration and repair of neural tissue using postpartum-derived cells

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Princeton, NJ, United States of America

Anthony J Kihm