Louisiana State University and Agricultural & Mechanical College

Other

National Institutes of Health (nih)

Raptor Pharmaceutical Corp

National Institutes of Health, a Component of the US Dept. of Health & Human Services

Message Pharmaceuticals, Inc.

B.v. Patel Pharmaceutical Education & Research Development (perd) Centre

B.v. Patel Pharmaceutical Education & Research Development (perd)

The National Institutes of Health and Axonyx, Inc.

Message Pharmaceutical, Inc.

Anthony J Giordano

Gordon Powers

Michael Alan Sturgess

Nigel H Greig

Arnold Brossi

Harold W Holloway

Donald K Ingram

Karen T Y Shaw

Qiang-Sheng Yu

Tada Utsuki

Diane M Davidson

Christopher Kevil

Timothy T Soncrant

Panayiotis P Constantinides

Douglas R Flanagan

Gajanan S Inamdar

Kamala K Vasu

Hardik M Thakar

Rajan S Giri

Vasudevan Sudarsanam

Swapnil G Yerande

Kyle Chan

Paul S Eder

Amol Soin

Timothy T Sencrant

Deborah Beach McGill

Gregg Johannes

Ke Yang

The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO). The pharmaceutical compositions of the invention are useful, for example, for treating or reducing pain, improving symptoms of a microvascular disease, and improving nerve conduction velocity.

Pharmaceutical formulations of nitrite and uses thereof

The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.

Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.

Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers

The present invention provides compounds and methods of administering compounds to a subject that can reduce &#x3b2;APP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce &#x3b2;APP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease &#x3b2;APP production.

Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof

The present invention provides compounds and methods of administering compounds to a subject that can reduce &#x3b2;APP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce &#x3b2;APP production and that is not tocix in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease &#x3b2;APP production.

Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof

Described herein are methods for identifying novel nucleic acid regulatory elements and compounds that modulate the regulation of such elements. Also described herein are nucleic acid sequence identified as novel nucleic acid regulatory elements and host cells containing such nucleic acid regulatory elements in a vector.

Methods for identifying novel nucleic acid regulatory elements and compounds that affect the regulation

The invention features screening assays for compounds that are potentially useful for treating or preventing a proliferative disease. The assays are based on contacting a candidate compound with a cell containing a nucleic acid including a HER2 regulatory element and a reporter sequence. In addition, the invention features compounds identified by the assays of the invention. The invention further features compounds structurally related to those identified by the screening assays. Finally, the invention features methods of treating or preventing a proliferative disease using the compounds of the invention.

Identification of compounds for the treatment or prevention of proliferative diseases

The methods and means are concerned with processes and devices useful in marking wallboard, paneling, and the like for the accurate definition of the limits of cut-outs to be formed to receive outlet boxes, switch boxes, and the like. In the preferred embodiment, the means comprise a substantially flat strip having a pair of spaced-apart cut-outs or recesses formed therein which, therebetween, define a triangular projection. Terminal, lateral portions of the strip are bent over upon themselves to define thereof a pair of resilient clips -- the clips being resiliently receivable by walls of such outlet boxes, and switch boxes, and the like, to cause the projection to extend from the strip and box wall for marking of wallboard, paneling, and the like to denote the box wall location. To accommodate the marking means for engagement with wall junctures of the boxes, the means is bent transverse to an elongate axis thereof; accordingly, each clip engages a distinct wall of the box, and the projection extends from the wall juncture. The forming method sets forth the process of forming the novel marking means from a strip of material, and the locations marking method discloses a process of impressing cut-out location markings on wallboard, paneling and the like which, especially, can be practiced with the novel marking means.

Cut-out locations marking method, means, and method of forming said means

Growing community of inventors

Wayne, NJ, United States of America

Anthony J Giordano