The University of Texas System

University of North Texas

The University of North Carolina at Chapel Hill

Anthony J Di Pasqua

Kenneth J Balkus, Jr

Imalka S Munaweera

Yi Shi

Michael Joseph Jay

Xiuling Lu

Iron garnet nanoparticles and or iron garnet particles containing various activatable nuclides, such as holmium-165 (Ho) and dysprosium-164 (Dy), are disclosed in this application. The iron garnet (e.g., HoIG and DyIG) nanoparticles and iron garnet particles can prepared using hydroxide co-precipitation methods. In some embodiments, radiosensitizers can be loaded on radioactive magnetic nanoparticles or radioactive iron garnet particles and, optionally, coated with suitable lipid bilayers. Methods of using the disclosed nanoparticles and particles for mediating therapeutic benefit in diseases responsive to radiation therapy are also provided. Another aspect of the invention provides films, electrospun fabrics or bandage coverings for the delivery of radiation to the site of a skin lesion amenable to treatment with radiation (e.g., skin cancers or psoriasis).

Iron garnet nanoparticles for cancer radiotherapy and chemotherapy

The present invention provides radiotherapeutic agents and compositions and methods for making and using the same. In some embodiments, the radiotherapeutic agent is a nanoparticle comprising a radionuclide and a carrier moiety. In some embodiments, the radionuclide is produced by activating a stable activatable particle via neutron activation.

Stable activatable particles as radiotherapeutic agents for the treatment of disease

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Fort Worth, TX, United States of America

Anthony J Di Pasqua