E.i. Dupont De Nemours and Company

Dupont Pharmaceuticals Company

Bristol-myers Squibb Compnay

Bristol-myers Squibb Pharma Company

Bristol-myers Squibb Pharma Corporation

Bristol-myers Squibb Holdings Ireland

Anthony J Cocuzza

James David Rodgers

Mona Patel

Frank W Hobbs

Haisheng Wang

Argyrios George Arvanitis

Paul Joseph Gilligan

Soo Sung Ko

Steven P Seitz

George A Boswell

Percy Sarwood Manchand

James Peter Beck

Wendel William Doubleday

Denis Favreau

Kathia Levesque

Rodney Lawrence Parsons, Jr

Eunhee Choi

Yvonne Lear

Markus Frieser

Shawn A Springfield

Donna M Bilder

Neil Alexander Straus

Abdul Ezaz Mutlib

David Donald Christ

Michel A Couturier

Robert J Zagursky

Jay Andrew Markwalder

Soonha Yang

Chunyoung Kim

Sangsoo Lee

Hyungcheol Kim

Frederic Buono

The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process.

Process for synthesizing substituted isoquinolines

The present invention relates to tricyclic 2-pyridone compounds of formula (I):or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.

Tricyclic-2-pyridone compounds useful as HIV reverse transcriptase inhibitors

5, 5-disubstituted-1, 5-dihydro-4, 1-benzoxazepin-2 (3H)-ones useful as HIV reverse transcriptase inhibitors

The present invention relates to 1,3-benzodiazepin-2-ones and 1,3-benzoxazepin-2-ones of formula I:

1,3-Benzodiazepin-2-ones and 1,3-Benzoxazepin-2-ones useful as HIV reverse transcriptase inhibitors

The present invention relates to benzoxazepinones of formula I: ##STR1## or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same and methods of using the same for treating viral infection or as an assay standard or reagent.

5,5-disubstituted-1,5-dihydro-4,1-benzoxazepin-2 (3H)-ones useful as HIV

Corticotropin releasing factor (CRF) antagonists of formula I: ##STR1## and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress in mammals.

Aryl- and arylamino- substituted heterocycles as corticotropin releasing

The present invention relates to benzoxazinones of formula I: ##STR1## or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, methods of using the same for treating viral infection or as an assay standard or reagent, and intermediates and processes for making the same.

4,4-disubstitued-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as HIV

A simplified method for isolating primer extension products and generating them in a form appropriate for electrophoresis is disclosed. The method is compatible with automated DNA sequencing procedures.

Method for sequencing DNA using biotin-strepavidin conjugates to

Alkynylamino-nucleotides and labeled alkynylamino-nucleotides useful, for example, as chain terminating substrates for DNA sequencing are provided along with several key intermediates and processes for their preparation.

Alkynylamino-nucleotides

Reagents useful in the preparation of 5'-biotinylated oligonucleotides are disclosed.

Reagents for the preparation of 5'-biotinylated oligonucleotides

Antihypertensive piperazineethylidenebenzocycloalkanes are provided. These compounds have the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are independently C.sub.1 -C.sub.6 alkyl, hydrogen, C.sub.1 -C.sub.6 alkoxy, hydroxy, or halo, or R.sub.1 and R.sub.2 or R.sub.2 and R.sub.3 together can form a methylenedioxy bridge;

Antihypertensive 1-[bis-(substituted

Certain 7-oxobicyclo[3.2.0] hept-2-en-2-carboxylic acids, esters, and salts thereof useful as antibacterial agents or as intermediates for antibacterial agents, and methods for making and using them.

Cyclobutanone antibacterials

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Wilmington, DE, United States of America

Anthony J Cocuzza