University of Miami

University System of Maryland

Stemsynergy Therapeutics, Inc.

Anthony J Capobianco

Mark Spyvee

Stephan C Schürer

Xiaoxia Zhu

Tanya T Kelley

Darren Orton

Alex Mackerell, Jr

Luisana Astudillo

Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: Formula (I), wherein the substituents are as described.

Inhibitors of the notch transcriptional activation complex and methods for use of the same

Disclosed herein are Notch transcriptional activation complex kinase (“MACK”) inhibitors, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein include compounds of Formula (Ia) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

Inhibitors of the Notch transcriptional activation complex kinase ('NACK') and methods for use of the same

Disclosed herein are Notch transcriptional activation complex kinase ('NACK') inhibitors, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein include compounds of Formula (la) and pharmaceutically acceptable salts thereof: wherein the substituents are as described. 

Inhibitors of the notch transcriptional activation complex kinase ('NACK') and methods for use of the same

Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: Formula (I), wherein the substituents are as described. 

Growing community of inventors

Miami Beach, FL, United States of America

Anthony J Capobianco