Smithkline Beecham Corporation

Anthony J Arleth

Xiaotong Li

Anne Romanic Arnold

Nabil A Elshourbagy

Usman Shabon

Robert N Willette

Yuan Zhu

HC/BTLP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hC/BTLP polypeptides and polynucleotides in the design of protocols for the treatment of restenosis, atherosclerosis, congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), benign prostatic hypertrophy (BPH), nephritis, fibrosis, glomerulonephritis, gliosis, cirrhosis and anomalies of wound healing, such as keloids among others, and diagnostic assays for such conditions.

Human cardiac/brain tolloid-like protein

The MT-MMP5-L polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing MT-MMP5-L polypeptides and polynucleotides in therapy, and diagnostic assays for such.

Splicing variant of human membrane-type matrix metalloproteinease-5 (MT-MMP5-L)

HCE3P83 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HCE3P83 polypeptides and polynucleotides in the design of protocols for the treatment of Alzheimer's Disease, stroke, cancer, inflammation, arthritis, musculoskeletal disease, heart disease and kidney disease, among others, and diagnostic assays for such conditions.

Membrane-type matrix metalloproteinase-5 gene

HCE3P83 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HCE3P83 polypeptides and polynucleotides in the design of protocols for the treatment of Alzheimer's Disease, stroke, cancer, inflammation, arhritis, musculoskeletal disease, heart disease and kidney disease, among others, and diagnostic assays for such conditions.

Growing community of inventors

Hatfield, PA, United States of America

Anthony J Arleth