May & Baker, Ltd.

Anthony H Loveless

Michael J Ashton

Garry Fenton

Robert Chapman

David Riddell

David C Cook

Andrew W Bridge

Colin J Daniels

Bernard T Bull

Jeremy D Pratt

Benzamide derivatives of the general formula: ##STR1## wherein A represents a divalent straight- or branched-chain alkylene group containing from 1 to 6 carbon atoms and R.sup.1 represents a halogen atom or a hydroxy, mercapto, amino, nitro, cyano, carboxy or carbamoyl group or an alkyl, fluorine-substituted alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkoxycarbonyl, alkylamino, dialkylamino, alkylcarbamoyl, dialkylcarbamoyl, alkanoyl, alkanoyloxy or alkanoylamino group and m represents zero or the integer 1, 2 or 3, R.sup.2 represents a hydrogen atom or an alkyl group, R.sup.3 represents a halogen atom or a hydroxy, amino, nitro, cyano, carboxy or carbamoyl group or an alkyl, fluorine-substituted alkyl, alkoxy, alkoxycarbonyl, dialkylamino, alkylcarbamoyl or alkanoylamino group and n represents zero or the integer 1 or 2, R.sup.4 represents and alkyl radical and p represents zero or the integer 1 or 2, or a pharmaceutically acceptable salt thereof, possess useful pharmacological properties.

Hypoglycaemic and hypolipidaemic benzamide substituted (1H-) imidazole

Indole and indoline derivatives of the formula: ##STR1## wherein  indicates a double bond or a single bond between carbon atoms, R.sup.1 represents hydrogen, alkyl of 1 through 6 carbon atoms, or alkyl of 1 through 6 carbon atoms substituted by one or more than one of the same type of substituents selected from the hydroxy group, alkenyl groups of 2 through 5 carbon atoms, and alkanoyloxy groups of 2 through 7 carbon atoms, and one of the symbols R.sup.2 represents alkyl of 6 through 24 carbon atoms and the other symbol R.sup.2 represents alkyl of 1 through 24 carbon atoms or hydrogen, and R.sup.3 represents alkyl of 1 through 6 carbon atoms or hydrogen, are new compounds possessing useful pharmacological properties. They are of use in the treatment of diabetes mellitus, hyperlipoproteinaemic states, of atherosclerosis, and of associated conditions.

Indole and indoline carboxylic acid compounds and method of use

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Hornchurch, United Kingdom

Anthony H Loveless