Aerase, Inc.

Immedica Pharma Ab

Anthony G Quinn

Scott W Rowlinson

David Lowe

Andreas Schulze

Ann Lowe

Methods and compositions therefor of treating GAMT deficiency or guanidino acetate (GAA) toxicity in a subject comprising administration of an arginine depleting enzyme. An therapeutic formulation can include an arginase, an arginine deiminase or a combination thereof and optionally other compounds, and can be adapted for intravenous or subcutaneous administration to a subject.

Arginine depletion therapy for treatment of GAMT deficiency

A method and composition to treat a subject with arginase 1 (ARG1) deficiency (ARG1-D) and to rapidly reduce the levels of at least one of arginine and/or a guanidino compound in the subject.

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Gloucester, MA, United States of America

Anthony G Quinn