Solazyme, Inc.

Danisco US Inc.

Genencor International, Inc.

Algenist Holdings, Inc.

University of Manitoba

Corbion Biotech, Inc.

Algenist Brands, LLC

Terravia Holdings, Inc.

Anthony G Day

Scott Franklin

Anna Coragliotti

Harrison F Dillon

Donald Eugene Trimbur

Chung-Soon Im

Geoffrey Brooks

Colin Mitchinson

Andrew Shaw

Peter Gualfetti

Frits Goedegebuur

Mats Sandgren

Jerry Stahlberg

Paulien Neefe

David Aaron Estell

Christopher J Murray

Scott Douglas Power

Anwar Zaman

Aravind Somanchi

Christopher James Murray

Jeff Avila

Stephen M Decker

Jon Wittenberg

Dan Elefant

Scott Harding

Peter J H Jones

David Brinkmann

Marc Kolkman

Katherine D Collier

Brian Frederick Schmidt

Anita Van Kimmenade

Yiyou Chen

Gudrun Vogtentanz

Deborah S Winetzky

Paulien Neefe-Kruithof

Jeffrey V Miller

Leif P Solheim

Carol A Requadt

Grant C Ganshaw

Hans De Nobel

Barbara A Swanson

Traci H Ropp

Dan Chen

Doreen Victoria

Beverley Rider Turnquest

Wei Geng

Raj Lad

Christopher Ringer

Harrison Fields Dillon

Kamalesh Rao

Paul T Jedzejewski

Beverly R Turnquest

Provided herein are microalgal skin care compositions and methods of improving the health and appearance of skin. Also provided are methods of using polysaccharides for applications such as topical personal care products, cosmetics, and wrinkle reduction compositions. The invention also provides novel decolorized microalgal compositions useful for improving the health and appearance of skin. The invention also includes insoluble polysaccharide particles for application to human skin.

Microalgae-derived compositions for improving the health and appearance of skin

Provided herein are microalgal polysaccharide compositions and. Also provided are methods of using polysaccharides for applications such as topical personal care products, cosmetics, and wrinkle reduction compositions. The invention also provides novel microalgal compositions useful for improving the health and appearance of skin. The invention also includes insoluble polysaccharide particles for application to human skin.

Microalgal polysaccharide compositions

Compositions for improving the health and appearance of skin

The invention provides methods of manufacturing alkanes from triglyceride oils produced through fermentation of oil-bearing microbes. The processes provided herein can utilize a variety of carbohydrate feedstocks including cane bagasse, sugar beet pulp, corn stover, glycerol, corn starch, sorghum, molasses, waste glycerol, and other renewable materials. These processes further comprise hydrotreating, hydrocracking, isomerization, distillation, and other petrochemical processes for use with oil-bearing microbes and products derived therefrom to manufacture fuels. Particular embodiments include the manufacture of ASTM D975 and ASTM D1655 compliant fuels. Genetically engineered microbes provided herein can be used in the manufacture of renewable diesel and renewable jet fuel.

Renewable diesel and jet fuel from microbial sources

Described herein are variants ofCBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.

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The invention is directed to methods of usingmicroalgal biomass in the treatment of individuals having impaired glucose metabolism. In some cases, the patient has impaired fasting glucose, impaired glucose tolerance, or diabetes. In some methods, algal biomass is used to reduce blood glucose and/or body fat in a subject, or to increase the relative abundance of beneficial gut microflora in a subject. In preferred embodiments, the biomass is derived fromcultures grown heterotrophically in which the algal cells comprise at least 15% algal oil by dry weight.

Methods of treating impaired glucose metabolism via administration of algal biomass

The invention generally relates to the production of hydrocarbon compositions, such as a lipid, in microorganisms. In particular, the invention provides methods for extracting, recovering, isolating and obtaining a lipid from a microorganism and compositions comprising the lipid. The invention also discloses methods for producing hydrocarbon compositions for use as biodiesel, renewable diesel, jet fuel, and other materials.

Fractionation of oil-bearing microbial biomass

The present invention provides peptides and supported peptides for treating various diseases and conditions. In particularly preferred embodiments, the present invention provides compositions and methods for personal care. In some embodiments the present invention provides compositions for use in skin and/or hair care, as well as cosmetic compositions. IN alternative particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein comprises BBI.

Peptide personal care compositions and methods for their use

The invention provides methods of cultivating oil-bearing microbes using xylose alone or in combination with other depolymerized cellulosic material. Also provided are microorganisms comprising an exogenous gene encoding a polysaccharide degrading enzyme, such as a cellulase, a hemicellulase, a pectinase, or a driselase. Some methods of microbial fermentation are provided that comprise the use of xylose and depolymerized cellulosic materials for the production of oil-bearing microorgansims.

Chlorella species containing exogenous genes

The invention provides methods of cultivating oil-bearing microbes using cellulosic material. Also provided are microorganisms containing one or more exogenous genes that facilitate the use of cellulosic materials as a feedstock. Also provided are microorganisms and methods for manufacturing non-alcohol-based fuels and fuel feedstocks through a process of converting cellulosic materials into oils.

Production of oil in microorganisms

Growing community of inventors

San Francisco, CA, United States of America

Anthony G Day