Emd Millipore Corporation

Amicon Ltd.

Anthony Frederick Mann

Venkatesh Natarajan

Daniel Schubnel

Vincenzo Vassarotti

Christopher R Bidell

Colin K Lanyl

Phillip Stafford

A method and device for packing a chromatography column formed of one or more vibration devices attached to top and/or bottom flanges of the column. Media is added in one or more steps to the column, allowed to settle under the effects of gravity and then subjected to one or more treatments of vibration from the vibration devices until a suitably packed column is obtained. Liquid used to suspend the media while being placed into the column may be at least partially removed before or during the vibration step(s). The remaining liquid is then removed or replaced after the packing has been obtained.

Method of and device for packing a chromatography column

A chromatography column piston 14 is adjustable in height within the column tube 4 by means of a friction clamp 22 which furthermore includes a threaded engagement with the associated end cap 8 of the column. As a result, with the friction clamp released the piston rod 16 can be rapidly traversed to or near a desired position, and the clamp then engaged following which cooperation of said threads allows fine tuning of the level of the piston 14 by fine adjustment of the position of the friction clamp relative to the end cap 8.

Chromatography column

A chromatography system comprises a chromatography column 1 consisting of a column tube 7 having end flanges 19 and 27 at its lower and upper ends, supporting an upper end cap 3 carrying a piston rod 9 and a piston 11. The system further comprises a container 20 for the separation media used in the chromatography column, this container having a neck ring 24 of injection moulded construction with a mouth end of a bag 22 embedded therein.

Chromatography system

Growing community of inventors

Malmesbury, United Kingdom

Anthony Frederick Mann