Celgene Corporation

Signal Pharmaceuticals, Inc.

Anthony Frank

Hon-Wah Man

Alexander L Ruchelman

Terrence Joseph Connolly

Jeffrey Manning Eckert

Chinnapillai Rajendiran

Jasti Venkateswaralu

Nallamaddi Ravikumar Reddy

Sreenivas S Bhat

Anthony J Tutino

Louise Michelle Cameron

Xiaozhong Liang

George W Muller

Peter Henry Schafer

Chuansheng Ge

Ying Li

Marie Georges Beauchamps

Antonio Christian Ferretti

Manohar Tukaram Saindane

Xiaoling Lu

Sai Shankar

Gondi Kumar

Roger S C Chen

Timothy D Fitzpatrick

Provided herein are compositions including the crystalline forms of (1E, 4E)-2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide ('Compound A'), methods of making the crystalline forms, and methods of using the crystalline forms for the treatment of diseases, including, for example, cancer.

Solid forms comprising (1E, 4E)-2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[B]azepine-4-carboxami compositions thereof, and uses thereof

Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-&#x3b1;. Further provided herein are processes for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine.

Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine

Provided herein are isoindole derivatives, which is enriched with isotopes such as deuterium. Pharmaceutical compositions comprising the isotopes-enriched compounds, and methods of using such compounds are also provided.

Isotopologues of isoindole derivatives

Provided herein are pharmaceutical formulations, comprising 4-((9-((3S)-tetrahydro-3-furanyl)-8-((2,4,6-trifluorophenyl)amino)-9H-purin-2-yl)amino)-trans-cyclohexanol, including pharmaceutically acceptable salts, solvates, isomers, isotopologues, tautomers and racemic mixtures thereof, and a pharmaceutically acceptable excipient; and their use for treating or preventing disease.

Pharmaceutical formulations of a substituted diaminopurine

Provided are phenethyl isoindoline compounds, and pharmaceutically acceptable salts, solvates, or stereoisomers thereof. Methods of use and pharmaceutical compositions of these compounds are also disclosed.

Phenethylsulfone isoindoline derivatives and their use

Provided are (methylsulfonyl)ethyl benzene isoindoline compounds, and pharmaceutically acceptable salts, solvates, or stereoisomers thereof. Methods of use and pharmaceutical compositions of these compounds are also disclosed.

(Methylsulfonyl) ethyl benzene isoindoline derivatives and their pharmaceutical uses

Methods for preparation of isoindolin-1-one compounds are described.

Processes for the preparation of 2-(1-phenylethyl)isoindolin-1-one compounds

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Easton, PA, United States of America

Anthony Frank