Genentech, Inc.

Constellation Pharmaceuticals, Inc.

F. Hoffmann-la Roche Ag

Anthony F Romero

Christopher G Nasveschuk

Brian K Albrecht

Steven R Magnuson

Alexander M Taylor

Terry Crawford

Alexandre Cote

Yves LeBlanc

Michael Charles Hewitt

Martin Duplessis

Vickie Hsiao-Wei Tsui

Steven F Bellon

Richard Pastor

Shumei Wang

Simon Charles Goodacre

Daniel J Burdick

Yun-Xing Cheng

Les A Dakin

Yong Tang

Andrew Charles Good

Wei Li

Terry Kellar

Gregory Hamilton

Paul Gibbons

The present invention relates to methods for treating PCAF and GCN5 mediated disorders using a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein ring A, R, R, R, R, and each Rhave any of the values defined in the specification. Also included are novel compounds of Formula (I) and salts thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.

Therapeutic compounds and uses thereof

The present invention relates to compounds of formula (I): and to salts thereof, wherein R, R, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.

Growing community of inventors

South San Francisco, CA, United States of America

Anthony F Romero