American Home Products Corporation

Other

Anthony F Kreft, Iii

John H Musser

Dennis Michael Kubrak

Amedeo A Failli

Reinhold H Bender

James Albert Nelson

Annette L Banker

Uresh Shantilal Shah

James J Bicksler

Thomas W Pattison

John W Giberson

Craig E Caufield

John P Yardley

Thomas Joseph Caggiano

Christopher A Demerson

Alexander A Greenfield

Stanley Charles Bell

Derek Cecil Cole

David S Casebier

Kevin R Woller

Robert J Steffan

Dieter H Klaubert

Kenneth L Kees

William Jay Moore

Joseph Raymond Stock

George Diamantidis

Lynn Resnick

Kristina Martha Kutterer

Winifred P Howse

Heterocyclic sulfonamide inhibitors of beta amyloid production

This invention provides compounds of formula I having the structure ##STR1## wherein R is (CH.sub.2).sub.n COOR.sup.4 ;

Pyranoindole and tetrahydrocarbazole inhibitors of COX-2

This invention provides compounds of formula I having the structure ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are, each, independently, hydrogen, alkyl, alkenyl, alkynyl, alkoxy, aralkoxy, trifluroalkoxy, alkanoyloxy, hydroxy, halo, trifluoromethyl, cyano, amino, mono- or di-alkylamino, alkanamido, or alkanesulfonamido;

Carbazole inhibitors of Cox-2

Pyranoindole inhibitors of COX--2

This invention relates to substituted indole derivatives possessing lipoxygenase inhibitory, phospholipase A.sub.2 inhibitory and leukotriene antagonist activity, which are useful as anti-inflammatory, antiallergic and cytoprotective agents.

Substituted indole-, indene-, pyranoindole- and

There are disclosed substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid derivatives and the pharmacologically acceptable salts thereof as inhibitors of PLA.sub.2 and lipoxygenase, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.

Substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid

There are disclosed compounds of the formula ##STR1## wherein R is hydrogen or lower alkyl;

Quinolinylmethoxy naphthalenepropionic acid derivatives as

There are disclosed compounds of the formula

Substituted benzoylbenzene-, biphenyl- and 2-oxazole-alkanoic acid

There are disclosed compounds of the formula ##STR1## wherein A is alkyl of 3-19 carbon atoms, diloweralkyl allyl, dihaloallyl, diphenylallyl, lower alkynyl, ##STR2## with the proviso that A is not quinolinyl; W is --CR.sub.2 O--, --CH.dbd.CH-- or --CH.dbd.CHCH.sub.2 O--;

Naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic

There are disclosed compounds of the formula ##STR1## wherein R is hydroxy, lower alkoxy or lower alkoxyamino;

2-anilino phenylacetic acid derivatives as inhibitors of PLA.sub.2 and

There are disclosed compounds of the formula ##STR1## wherein X is ##STR2## Y is ##STR3## Z is --(CH.sub.2).sub.n O--, --(CH.sub.2).sub.n S--, ##STR4## R.sup.1 is ##STR5## n is 0-5; R.sup.2 is hydrogen, loweralkyl, loweralkoxy, lower alkoxycarbonyl, trifluoromethyl, nitro, cyano or halo;

Certain

There are disclosed compounds of the formula ##STR1## wherein a is alkyl 3-19 carbon atoms, diloweralkyl allyl, diahaloallyl, diphenylallyl, lower alkynyl, ##STR2## W is --CR.sub.2 O--, --CH.dbd.CH-- or --CH.dbd.CHCH.sub.2 O-- X is N or CR;

Quinoline substituted naphthalenepropionic acid derivatives as

2-Anilino phenylacetic acid derivatives

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Langhorne, PA, United States of America

Anthony F Kreft, Iii