Endo Pharmaceuticals Inc.

Purdue Pharma L.p.

Richardson Vicks, Inc.

Penwest Pharmaceuticals Company

Euro-celtique S.a.

Anthony E Carpanzano

Benjamin Oshlack

Anand R Baichwal

Philip A Goliber

Donald Diehl

David Verbel

Curtis Wright

Richard S Sackler

Thomas Sciascia

Brian Vogler

Stanley Au

Ihor Shevchuk

William J Kelleher

Lino Tavares

Rampurna Prasad Gullapalli

Bruce E Reidenberg

James P Cassidy

Mark A Alfonso

Donald Ii Diehl

Sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof; methods for making the sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof; and methods for using the sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof to treat patients suffering from pain are provided.

Sustained release formulations of nalbuphine

Sustained release formulation of nalbuphine

The present invention provides an oral dosage form comprising a first composition and a second composition. The first composition comprises an effective amount of a therapeutic agent and the second composition comprises an effective amount of an adverse-effect agent. The adverse-effect agent is covered with a coating that is substantially insoluble in the gastrointestinal tract. In one embodiment, the adverse-effect agent is coated with an outer base-soluble layer and an inner acid-soluble layer. The therapeutic agent can be uncoated or can be coated with a coating having an outer acid-soluble layer and an inner base-soluble layer. The dosage form discourages administration of the therapeutic agent by other than oral administration.

Oral dosage form comprising a therapeutic agent and an adverse-effect agent

Disclosed are oral pharmaceutical preparations which comprise a pharmacologically active drug bound to small particles of an ion-exchange resin to provide a drug-resin complex having a drug content above a specified value. The drug-resin complex is subsequently coated with a water-permeable diffusion barrier coating that is insoluble in gastrointestinal fluids thereby providing a controllable sustained release of drug under conditions encountered in the gastrointestinal tract.

Sustained release drug-resin complexes

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New Milford, CT, United States of America

Anthony E Carpanzano