Warner-lambert Company

Other

British Technology Group Limited

Berry and Associates, Inc.

Glen Research Corporation

British Tech. Group

Anthony Denver Sercel

Howard D Showalter

Michael Francis Rafferty

Yuntao Song

Lain-Yen Hu

Vladimir Genukh Beylin

Todd Robert Ryder

Gerald E Adams

Ian J Stratford

Edward M Fielden

Matthew A Naylor

David T Connor

Bruce D Roth

Om Prakash Goel

Edward Faith Elslager

Thomas C Malone

Leslie M Werbel

Daniel Fred Ortwine

David B Capps

David A Berry

Donald F Worth

Vlad E Gregor

Ellen M Berman

Hugh Mackie

Dean S Wise

Kee-Yong Jung

John B Randolph

Robert L Somers

A fluorescent nitrogenous base and nucleosides including the fluorescent nitrogenous base are provided. Nucleosides including the fluorescent nitrogenous base are capable of Watson-Crick base pairing with naturally occurring nucleosides. The nucleosides including the fluorescent nitrogenous base have many uses including but not limited to use in probes, in the synthesis of nucleic acids, and in investigating nucleic acid interactions with other nucleic acids and/or with proteins.

Fluorescent nitrogenous base and nucleosides incorporating same

The present invention provides compounds that block calcium channels having the Formula I shown below. The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, asthma, amyotropic lateral sclerosis, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.

Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers

Substituted diarylalkyl amides as calcium channel antagonists

The present invention provides compounds that block calcium channels having the Formula I shown below. ##STR1## The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, asthma, amyotropic lateral sclerosis, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.

Chiral compounds useful as radiosensitizers or chemosensitizers having the formula ##STR1## wherein X is halogen or ##STR2## intermediates used to prepare these compounds, and a novel process to prepare these compounds are described.

Chiral [[(2-bromoethyl)-amino]methyl]-2-nitro-1H-imidazol-1-ethanol and

Process for preparing chiral

Improved processes for producing substituted benzo(chalcogeno)[4,3,2-cd] indazoles. The processes produce compounds in higher yields and of greater purity by using a novel sequence of acylation chemistry and easily removed protecting groups. The compounds produced have antibacterial, antifungal, antileukemic, and antitumor activity.

Processes for the preparation of benzo(chalcogeno)(4,3,2-cd)indazoles

Substituted 2H-[1]benzopyrano[4,3,2-cd]indazoles, 2H-[1]benzothiopyrano[4,3,2-cd]indazoles, and 2H-[1]benzoselenino[4,3,2-cd]indazoles have demonstrated pharmacological activity against a broad spectrum of Gram-positive and Gram-negative bacteria, yeasts, and fungi, as well as activity against the L1210 and P388 murine leukemia cells lines. Pharmaceutical compositions containing the compounds and methods of employing the compounds in methods of treating bacterial or fungal infections and of inhibiting the growth of neoplasms in mammals are also disclosed.

Antibacterial benzo(chalcogeno)[4,3,2-cd]indazoles

Growing community of inventors

Ann Arbor, MI, United States of America

Anthony Denver Sercel