Albert Einstein College of Medicine

Industrial Research Limited

Victoria Link Limited

Anthony David Woolhouse

Vern L Schramm

Peter Charles Tyler

Shivali Ashwin Gulab

Richard Hubert Furneaux

Gary Brian Evans

Keith Clinch

Peter Michael Kelly

Douglas Ronald Crump

Quan Du

Farah Lamiable-Oulaidi

Karl Jürgen Shaffer

Ashna Ashneen Khan

Provided herein are inhibitors of DNA methyltransferase 1 (an enzyme responsible for the maintenance of DNA CpG methylation marks in human cells) and their use for inhibiting DNA methyltransferase 1. The invention relates to compounds, pharmaceutical compositions, and methods for inhibiting DNA methyltransferase 1. The inhibitors are compounds of the general formula: 

Inhibitors of DNMT1 as anticancer therapeutic agents

The invention relates to compounds of the general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNPs) and/or nucleoside hydrolases (NHs). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.

Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases

Growing community of inventors

Wellington, New Zealand

Anthony David Woolhouse