Battelle Memorial Institute

Eli Lilly and Company

The Ohio State University

Anthony David Duong

Cherry Gupta

Danielle J Huk

Kenneth R Sims, Jr

Ramanathan S Lalgudi

Rachel R Spurbeck

Amy M Heintz

Chad M Cucksey

Randy L Jones

Stephanie Kute

Phillip N Denen

Craig Bartling

Michael D Crenshaw

Jacob Lilly

Mike Koeris

Richard Mon Che Chou

Andrea D Mccue

Lampros Kourtis

Jeffrey L Ellis

Corrie Bennison

Erik W Edwards

Michael Sandor Koeris

John Paul Tallarico

Michael W Harrison

Rhea Sirkar

Jessica Winter

Barbara Wyslouzil

Nickolas R Andrioff

Julianne Np Smith

Michael Riedl

Gang Ruan

Katarzyna Kucharzyk

Jane P Fife

James Ha

Miguel D Pedrozo

Kalpesh Mahajan

Michael Wagner

Ashlee J Colbert

Jacqueline Grible

Zachary R Shank

Emma K Schmitz

Caleb T Hillrich

Shannon D Miller

Jessica O Winter

Joanna L Hoy

Jeffrey Leclair Ellis

Lampros C Kourtis

Corrie Jo Bennison

Craig M Bartling

The disclosure relates to block copolymer nanoparticles for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, for delivering nucleotides that encode polypeptides.

Polymer nanoparticle compositions for in vivo expression of polypeptides

The present disclosure is directed to compositions and methods that use the principles of DNA origami to package and archive data stored in multiple indexed DNA oligonucleotides. These structures allow for selective physical data access and retrieval from a molecular pool of DNA origami (DNAO) nanostructures comprising the data bearing oligonucleotides.

Use of DNA origami nanostructures for molecular information based data storage systems

The invention relates to polymer nanoparticle and DNA nanostructure delivery compositions for non-viral delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticle delivery compositions, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, and DNA nanostructure delivery compositions, such as DNA origami compositions, for the delivery of more than one payload, or for the delivery of a nucleic acid construct payload of 3 kB or more, and methods therefor.

Polymer nanoparticle and DNA nanostructure compositions and methods for non-viral delivery

Disclosed herein are coatings made from a biocompatible controlled release polymer and an active component. The active component can be, for example, an antimicrobial agent, an immune modulating agent, a cell signaling factor, or a growth factor. The coating has micrometer and nanometer scale features on the surface thereof.

Coatings for biological interface on implants

Polymer matrix particles useful for inhibiting scale formation in oil and gas wells are described. The insoluble, porous, crosslinked polymer matrix includes a polymer backbone and ionic functional groups covalently bonded to the backbone, the ionic functional groups being capable of selectively attracting and binding salt scale-forming ions when in contact with a liquid containing such ions.

Polymer matrix particles for inhibiting scale formation in oil and gas wells

An agricultural composition comprises living microorganisms encapsulated in polymer gel microbeads which are applied onto seeds. In another embodiment, an agricultural composition comprises living microorganisms encapsulated in polymer gel macroheads for planting with seeds in soil. In another embodiment, an agricultural composition comprises living microorganisms immobilized in a polymer gel matrix that is coated on a seed.

Encapsulation for microbial seed treatment stabilization

The disclosure relates to barcoded polymer nanoparticles for in vivo screening and for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, associated with polynucleotide barcodes, for therapeutic delivery, and for high throughput in vivo screening of drug delivery nanoparticles.

Rapid design, build, test, and learn technologies for identifying and using non-viral carriers

A chemical reaction system is disclosed for use in a device for delivering a therapeutic fluid comprising a liquid base and a polymeric acid. A reaction rate of the chemical reaction system is capable of being adjusted by adjusting at least one of surface area-to-volume ratio, acid concentration, and cross-linking of the polymeric acid.

System for controlling gas generation within a drug delivery device

The invention relates to control compositions for sequencing and for chemical analyses, such as analytical chemistry analyses. More particularly, the invention relates to control compositions for sequencing and for chemical analyses having at least one barcode sequence fragment and at least one universal sequence fragment, and to methods of their use.

Methods and control compositions for sequencing

Control compositions and methods for sequencing

A method of making CNT films is described in which the film is washed with a mild acid treatment. The method generates a CNT film that is not sensitive to moisture or fluctuations in moisture. The method involves the use of anionic polysaccharides or anionic glycosaminoglycans such as hyaluronic acid, sodium salt, as aqueous dispersing agents and their modification to a hydrophobic matrix after deposition. In the course of conducting the work described here, we made the surprising discovery that washing with an aqueous acidic solution resulted in a decrease in resistance through the material. The invention also includes CNT composites made by the inventive methods and a CNT composite comprising CNTs and anionic polysaccharides or anionic glycosaminoglycans further characterized by a low cationic content and a high conductivity and/or small CNT particle size as measured by SEM.

Stabilization of carbon nanotube coatings

Stabilization of carbon nanotube coatings to moisture

A method for producing nanocomposite particles is provided. The method comprises supplying an organic phase fluid an organic phase fluid, an aqueous phase fluid, an amphiphile, and a plurality of hydrophobic nanospecies to a nozzle. An electric field is generated proximate the nozzle such that the fluid exiting the nozzle forms a cone jet that disperses into a plurality of droplets. The plurality of droplets are collected, and nanocomposite particles comprising a self-assembled structure encapsulating at least one hydrophobic nanospecies form by self-assembly.

Methods for producing nanoparticles and using same

Growing community of inventors

Columbus, OH, United States of America

Anthony David Duong