Curis, Inc.

Novartis Ag

Isis Pharmaceuticals, Inc.

Oxford Asymmetry International Plc

Curtis, Inc.

Anthony David Baxter

Stephen Colin Price

Edward Andrew Boyd

Oivin M Guicherit

Lee L Rubin

John Harry Alexander Stibbard

Maria Frank-Kamenetsky

Jeffrey A Porter

Jeffery Porter

Stephen Paul Collingwood

Roger John Taylor

Robin Alec Fairhurst

Eric K Baylis

Mario Eugenio Polywka

Mark Edward Douglas

Lee D Rubin

Daniel John Bayston

Edwin Moses

Mark Richard Ashton

The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS.and. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Small organic molecule regulators of cell proliferation

The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Mediators of hedgehog signaling pathways, compositions and uses related thereto

The present invention makes available methods and reagents for inducing activation of a hedgehog pathway in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as a small molecule, in a sufficient amount to achieve a therapeutic result. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Agonists of hedgehog signaling pathways and uses related thereto

A compound represented in general formula (X) and (XI):

The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. and In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Oligonucleotide analogues

The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.

Compounds of Formula (I) wherein R, R.sup.1, R.sup.2 and R.sup.9 are as herein defined, processes for their preparation and transition metal complexes comprising such compounds are disclosed. The complexes may be attached to insoluble supports and are useful as asymetric catalysts. ##STR1##

Phosphine ligands

Dinucleotide and oligonucleotide analogues

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Abingdon, United Kingdom

Anthony David Baxter