Breathe Technologies, Inc.

Pulmonx Corporation

Capnia, Incorporated

Other

Soleno Therapeutics, Inc.

Menlo Lifesciences, LLC

Anthony D Wondka

Joseph Cipollone

Todd W Allum

Gregory J Kapust

Darius D Eghbal

Joey Aguirre

Anthony Gerber

Lutz Freitag

Peter P Soltesz

George A Kassanis

Robert Kotmel

Anish Bhatnagar

Rodney C Perkins

Robert M Bryan

Darius Eghbal

Nikolai Aljuri

Enrico Brambilla

George Surjan

Pedro E De La Serna

Rodney A Perkins

Nadia Matov

Michael Khenansho

Jose J Aguirre, Jr

Thomas Crowder

Cuong Q Tran

Mark McCall

Kirk Davis

Gregory Kapust

Todd Allum

Antony Jonathan Fields

Elvir Causevic

John G McCutcheon

Scott Jay Gilbert

Otho Newman Boone

Jose J Aguirre

Todd A Allum

Angela King

Constantine Andrew Gillespie

Robert Bryan

Jeffrey Lee

Jr Jose J Aguirre

Joe Cipollone

Robert F Bryan

Scott J Gilbert

A system for reducing airway obstructions of a patient may include a ventilator, a control unit, a gas delivery circuit with a proximal end in fluid communication with the ventilator and a distal end in fluid communication with a nasal interface, and a nasal interface. The nasal interface may include at least one jet nozzle, and at least one spontaneous respiration sensor in communication with the control unit for detecting a respiration effort pattern and a need for supporting airway patency. The system may be open to ambient. The control unit may determine more than one gas output velocities. The more than one gas output velocities may be synchronized with different parts of a spontaneous breath effort cycle, and a gas output velocity may be determined by a need for supporting airway patency.

Methods, systems and devices for non-invasive ventilation with gas delivery nozzles in free space

A non-invasive ventilation system may include a nasal interface. The nasal interface may include a left outer tube with a distal end adapted to impinge a left nostril, at least one left opening in the left distal end in pneumatic communication with the left nostril, and a left proximal end of the left outer tube in fluid communication with ambient air. The left proximal end of the left outer tube may curve laterally away from a midline of a face. A right outer tube may be similarly provided. One or more left jet nozzles may direct ventilation gas into the left outer tube, and one or more right jet nozzles may direct ventilation gas into the right outer tube. The jet nozzles may be in fluid communication with the pressurized gas supply.

Methods, systems and devices for non-invasive open ventilation with gas delivery nozzles within nasal pillows

Systems and methods may include a gas source, a gas delivery circuit, and a nasal interface allowing breathing ambient air through the nasal interface. A gas flow path through the nasal interface may have a distal gas flow path opening. A nozzle may be associated with a proximal end of the nasal interface a distance from the distal end gas flow path opening. At least a portion of an entrainment port may be between the nozzle and the distal end gas flow opening. The nozzle may deliver gas into the nasal interface to create a negative pressure area in the gas flow path at the entrainment port. The nasal interface and the nozzle may create a positive pressure area between the entrainment port and the distal end gas flow path opening. Gas from the gas delivery source and air entrained through the entrainment port may increase airway pressure or lung pressure or provide ventilatory support.

Methods, systems and devices for non-invasive ventilation including a non-sealing ventilation interface with an entrainment port and/or pressure feature

A non-invasive ventilation system may include at least one outer tube with a proximal lateral end of the outer tube adapted to extend to a side of a nose. The at least one outer tube may also include a throat section. At least one coupler may be located at a distal section of the outer tube for impinging at least one nostril and positioning the at least one outer tube relative to the at least one nostril. At least one jet nozzle may be positioned within the outer tube at the proximal lateral end and in fluid communication with a pressurized gas supply. At least one opening in the distal section may be adapted to be in fluid communication with the nostril. At least one aperture in the at least one outer tube may be in fluid communication with ambient air. The at least one aperture may be in proximity to the at least one jet nozzle.

Methods, systems and devices for non-invasive open ventilation with gas delivery nozzles with an outer tube

Methods and systems are described to obtain and analyze one or more gas samples from the breath of a person, and organizing the samples in a sample registry for subsequent analysis. This technique solves the various problems that are associated with targeting an individual breath for analysis, and allows for additional versatility and options in the analysis process.

Sampling and storage registry device for breath gas analysis

A breath parameter measuring device is described which takes into account breathing patterns which historically have been incompatible with accurate measurements. In particular, during fast breathing patterns, the sensor performing the measurement may not be able to respond quickly enough to provide the true reading. The disclosure may be useful for example in the case of neonatal breath carbon dioxide measurements.

Neonatal carbon dioxide measurement system

Resuscitation apparatuses and methods for assisted ventilation are described herein. The apparatuses may include functional elements that allow the manual delivery of a prescribed volume to an adult or an infant lung. Furthermore, the apparatuses may inform and assure an emergency worker that an appropriate volume is being delivered and therefore lessen the possibility of barotrauma from over-delivery, or ventilatory distress from under-delivery. In some embodiments, the apparatuses include biomechanical and ergonomic functional elements that allow an adult hand to hold it in place during operation, while at the same time, allowing the user to actuate the apparatus to deliver only the necessary amount of volume suitable for an infant lung. In other embodiments, a volume-controlled design is applied to pediatric and adult resuscitation.

Resuscitation bag

Apparatuses are described to accurately determine a gas concentration of a sample of a patient's breath. The apparatuses may include a sample compartment, a breath speed analyzer, a gas analyzer, and a processor. The sample compartment includes an inlet that receives the breath. The breath speed analyzer determines the speed of a portion of the breath. The gas analyzer determines a gas concentration. The processor includes an algorithm that determines a degree of non-homogeneity of the sample based on the speed, and a corrected gas concentration based on the degree of non-homogeneity. In some variations, the gas correction is determined independently of patient cooperation. Apparatuses may be tuned based on the intended population's expected breathing pattern ranges such that the sample compartment is filled with a homogenous end-tidal gas sample regardless of an individual's breathing pattern. These apparatuses are useful, for example, for end-tidal CO analysis. Methods are also described.

Collection and analysis of a volume of exhaled gas with compensation for the frequency of a breathing parameter

A non-invasive ventilation system may include a nasal interface. The nasal interface may include a left outer tube with a left distal end adapted to impinge a left nostril, at least one left opening in the left distal end in pneumatic communication with the left nostril, and a left proximal end of the left outer tube in fluid communication with ambient air. The left proximal end of the left outer tube may curve laterally away from a midline of a face. A right outer tube may be similarly provided. One or more left jet nozzles may direct ventilation gas into the left outer tube, and one or more right jet nozzles may direct ventilation gas into the right outer tube. The jet nozzles may be in fluid communication with the pressurized gas supply.

Methods for administering immune globulin and devices for use thereof. The methods may generally include measuring a patient's hemolysis levels and determining whether the patient is suitable for immune globulin treatment, determining whether immune globulin treatment should be continued, and/or determining if the dose needs to be changed.

Methods for immune globulin administration

Methods and systems are described to obtain and analyze a gas sample from a desired section of the breath of a person, while accounting for erratic, episodic or otherwise challenging breathing patterns that may otherwise make the capturing of a gas sample from the desired section of breath difficult. These techniques may provide more reliable, accurate and adequate samples of gas such as end-tidal gas, and ultimately an accurate analysis of the sample captured.

Breath selection for analysis

Growing community of inventors

Mountain View, CA, United States of America

Anthony D Wondka