Northeastern University

Anthony D'onofrio

Kim Lewis

Akira Iinishi

Charlotte Berkes

Yu Imai

Xiaoqian (Wendy) Wu

Thomas Curtis

Nadja Leimer

Assays for compounds having a desired biological activity against one but not both of a pair of microorganism species utilize separately detectable labels. The first and second microorganisms are different from each other, the first microorganisms exhibit a first detectable label, the second microorganisms exhibit a second detectable label different from the first detectable label, and neither of the labels interferes with detection of the other label. In various embodiments, the first and second microorganisms are incubated with a candidate compound or a producer thereof. The different labels permit isolation of microorganisms exhibiting one of the labels but not the other, indicating the desired activity, and the compound responsible for this differential response is isolated.

Selectivity screening for antimicrobial compounds

This invention provides, among other things, compounds useful for treating spirochete diseases such as Lyme disease, as well as pharmaceutical formulations and/or environmental baits containing such compounds.

Hygromycin a compounds and methods of treating spirochete diseases

Growing community of inventors

Northborough, MA, United States of America

Anthony D'onofrio