University of California

Medimmune Limited

Anthony Cormier

James David Marks

Jianlong Lou

Ping Tsui

Jody Lynn Baron

Stephen L Nishimura

Yifan Cheng

Shenping Wu

Naoki Takasaka

Saburo Ito

Melody G Campbell

Lynne Murray

Antibodies that bind to αvβ8 are provided.

Antibodies that bind integrin αvβ8 and uses thereof

New antibodies and methods of use are described.

Neutralizing antibodies to the αvβ8 integrin complex for immunotherapy

Antibodies that bind to &#x3b1;&#x3bd;&#x3b2;8 are provided.

Antibodies that bind integrin AVB8 and uses thereof

Neutralizing antibodies to the alpha v beta 8 integrin complex for immunotherapy

Provided is an antibody that specifically binds human &#x3b1;v&#x3b2;&#x3b2; and blocks binding of TGFp peptide to &#x3b1;v&#x3b2;8, wherein the antibody binds to the specificity determining loop (SDL) of human &#x3b2;8. In some embodiments, the antibody further binds to one, two, or all three of the human av-head domain, the al helix of human &#x3b2;8, or the al helix of human &#x3b2;8. In some embodiments, the antibody is humanized or chimeric. In some embodiments, the antibody is linked to a detectable label. Also provided is a method of enhancing an immune response in a human individual, comprising administering a sufficient amount of the antibody to the individual, thereby enhancing an immune response. Also provided are pharmaceutical compositions comprising the anti-&#x3b1;v&#x3b2;&#x3b2; antibodies or antigen-binding molecules thereof.

Neutralizing antibodies to the &#x3b1;v&#x3b2;8 integrin complex for immunotherapy

Growing community of inventors

San Francisco, CA, United States of America

Anthony Cormier