University of Washington

Phaserx, Inc.

Genevant Sciences Gmbh

Anthony Convertine

Patrick S Stayton

Allan Sachs Hoffman

Paul Hickok Johnson

Craig L Duvall

Robert W Overell

Anna S Gall

Danielle Benoit

Mary Gallagher Prieve

Charbel Diab

Priyadarsi De

Amber E E Paschal

Pierre D Mourad

Richard Glen Ellenbogen

Forrest M Kievit

Donghoon Lee

Scott M Henry

Menko P Ypma

Peter A Chiarelli

Joshua Sang Hun Park

Julia Mengyun Xu

Daniel M Ratner

Selvi Srinivasan

Amber Ee Paschal

Debobrato Das

Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.

Oxygen reactive polymers for treatment of traumatic brain injury

Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.

Micellic assemblies

Polymeric carriers for the delivery of therapeutic agents and methods for making and using the same. The polymeric carriers include copolymers, diblock copolymers, polymeric architectures that include the copolymers and diblock copolymers, and particles assemblies comprising the copolymers, diblock copolymers, and polymeric architectures that include the copolymers.

Stabilized polymeric carriers for therapeutic agent delivery

Polymeric compounds having spatially controlled bioconjugation sites are described. Functionalization is achieved by selective &#x3c9;-terminal chain extension of polymer chains by radical polymerization, such as reversible addition-fragmentation chain transfer (RAFT) polymerization.

&#x3c9;-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization

Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.

Diblock copolymers and polynucleotide complexes thereof for delivery into cells

Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.

Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization

A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.

Bispecific intracellular delivery vehicles

Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.

Polymeric carrier

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Seattle, WA, United States of America

Anthony Convertine